Department of Gynecologic Oncology, Peking University School of Oncology, Beijing Cancer Hospital & Institute, Beijing, China.
Chin Med J (Engl). 2011 Feb;124(4):622-6.
Unlike other non-gynecologic solid tumors, such as breast cancer, lung cancer, metastasis to bone from endometrial carcinoma is rare, metastasis to extremity is extremely rare. We report a 51-year-old multiparous woman with FIGO Stage IVb Grade 2 endometrial adenocarcinoma which metastasized to left lower extremity bone. She received an amputation of left lower extremity below the knees, and a total abdominal hysterectomy and bilateral salpingo-oophorectomy, and followed by systemic chemotherapy, radiation therapy to the pelvis and progestational agent. She had a complete response to above treatments, and disease-free survival for 10 months. After recurrence, she received chemotherapy, radiotherapy and progestational agent once again. She had lived 56 months and is still alive by the time of report. Metastasis of endometrial carcinoma to extremity bone can rarely occur and should be considered when the patient with endometrial carcinoma complained of unexplained pain and swelling associated with extremity bone.
与其他非妇科实体瘤（如乳腺癌、肺癌）不同，子宫内膜癌转移至骨较为少见，转移至四肢则更为罕见。我们报告了一例 51 岁的多产妇，患有国际妇产科联盟（FIGO）分期为 IVb 级 2 期的子宫内膜腺癌，转移至左下肢骨。她接受了左下肢膝下截肢术，以及全子宫切除术和双侧输卵管卵巢切除术，并随后进行了全身化疗、骨盆放疗和孕激素治疗。她对上述治疗完全有反应，无病生存期为 10 个月。复发后，她再次接受了化疗、放疗和孕激素治疗。截至报告时，她已经生存了 56 个月，仍然存活。子宫内膜癌转移至四肢骨的情况很少见，当患有子宫内膜癌的患者出现不明原因的疼痛和与四肢骨相关的肿胀时，应考虑这种情况。
