Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Chin Med J (Engl). 2011 Feb;124(3):445-56.
This review discusses the current status and progress in studies on gastric cancer with liver metastasis (GCLM), involving the routes, subtypes, and prognosis of GCLM; the genes and molecules associated with metastasis; the feasibility and value of each imaging modality; and current treatment options.
The data used in this review were mainly from Medline and PubMed published in English from 2005 to August 2010. The search terms were "gastric cancer" and "liver metastasis".
Articles regarding the characteristics, diagnostic modalities, and various therapeutic options of GCLM were selected.
The prognosis of GCLM is influenced by the clinicopathological characteristics of primary tumors, as well as the presence of liver metastases. Improved understanding of related genes and molecules will lead to the development of methods of early detection and targeted therapies. For the diagnosis of GCLM, each imaging modality has its relative benefits. There remains no consensus regarding therapeutic options.
Early detection and characterization of liver metastases is crucial for the prognosis of gastric cancer patients. Multidisciplinary team discussions are required to design optimal treatment strategies, which should be based on the clinicopathological characteristics of each patient.
本文综述了胃癌伴肝转移（GCLM）的研究现状和进展，涉及 GCLM 的转移途径、亚型和预后、与转移相关的基因和分子、每种影像学模式的可行性和价值，以及目前的治疗选择。
本综述中使用的数据主要来自 2005 年至 2010 年 8 月在英文期刊 Medline 和 PubMed 上发表的文章，检索词为“gastric cancer”和“liver metastasis”。
选择了关于 GCLM 的临床病理特征、诊断方式和各种治疗选择的文章。
GCLM 的预后受原发肿瘤的临床病理特征以及肝转移的存在的影响。对相关基因和分子的深入了解将导致早期检测和靶向治疗方法的发展。对于 GCLM 的诊断，每种影像学模式都有其相对的优势。对于治疗选择，目前尚无共识。
早期检测和明确肝转移对胃癌患者的预后至关重要。需要多学科团队讨论来制定最佳治疗策略，该策略应基于每位患者的临床病理特征。
