Ghent Research Group on Nanomedicines, Lab of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000 Gent, Belgium.
J Control Release. 2011 Jun 10;152(2):249-56. doi: 10.1016/j.jconrel.2011.02.024. Epub 2011 Feb 26.
Liposome-loaded microbubbles have been recently introduced as a promising drug delivery platform for ultrasound guided drug delivery. In this paper we design liposome-loaded (lipid-shelled) microbubbles through the simple self-assembly of the involved compounds in a single step process. We thoroughly characterized the liposome-loading of the microbubbles and evaluated the cell killing efficiency of this material using doxorubicin (DOX) as a model drug. Importantly, we observed that the DOX liposome-loaded microbubbles allowed killing of melanoma cells even at very low doses of DOX. These findings clearly prove the potential of liposome-loaded microbubbles for ultrasound targeted drug delivery to cancer tissues.
脂质体负载的微泡最近被引入作为一种有前途的超声引导药物传递的药物传递平台。在本文中，我们通过在单个步骤中简单地自组装涉及的化合物来设计脂质体负载（脂质壳）的微泡。我们彻底表征了微泡的脂质体负载，并使用阿霉素（DOX）作为模型药物评估了该材料的细胞杀伤效率。重要的是，我们观察到 DOX 脂质体负载的微泡甚至在非常低剂量的 DOX 下也能杀死黑色素瘤细胞。这些发现清楚地证明了脂质体负载的微泡用于超声靶向递送至癌症组织的潜力。
