磷酸化-EZH 离子。
Phosphoryl-EZH-ion.
机构信息
Department of Biomolecular Sciences and Biotechnology, University of Milan, 20133 Milan, Italy.
出版信息
Cell Stem Cell. 2011 Mar 4;8(3):262-5. doi: 10.1016/j.stem.2011.02.012.
Abstract
Polycomb group (PcG) proteins regulate gene expression in embryonic and adult stem cells, but the mechanisms responsible for PcG gene targeting and regulation remain largely unknown. Recent evidence shows that EZH2, the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), is a nuclear phosphoprotein linking cell-cycle-intrinsic or extracellular signals to specific epigenetic signatures.
摘要
多梳抑制复合物（PcG）蛋白在胚胎和成体干细胞中调节基因表达，但负责 PcG 基因靶向和调控的机制在很大程度上仍然未知。最近的证据表明，EZH2 是 Polycomb 抑制复合物 2（PRC2）的酶亚基，是一种将细胞周期内在或细胞外信号与特定表观遗传特征联系起来的核磷酸蛋白。
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Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA.PRC2 组件 Ezh2 的磷酸化受细胞周期调控，并上调其与 ncRNA 的结合。
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