Ida T, Ukikusa M, Yamamoto M, Nakase A, Ozawa K, Tobe R
Circ Shock. 1978;5(4):383-91.
In hemorrhagic shocked rats, the hepatic energy charge (ATP+1/2ADP)/(ATP+ADP+AMP) fell rapidly from 0.857 to 0.542 within 2 hours and was rapidly restored to normal levels after completing the reinfusion of shed blood. The total adenine nucleotide levels decreased slowly from 3.83 to 2.57 mumoles per g wet liver 2 hours after shock, and increased to normal levels 2 hours after reinfusion of shed blood. The intraperitoneal injection of 2 mg adenosine/100g body weight, 85 mg glucose/100 g body weight and 3.3 units insulin/100 g body weight, simultaneously with the reinfusion of shed blood, enhanced the recovery of energy charge and adenine nucleotide levels. The injection of 2 mg adenosine alone was ineffective in restoring the energy charge. However, administration of more than 6.7 mg adenosine/100 g body weight enhanced recovery of energy charge and adenine nucleotide levels, whether insulin was added or not.
在失血性休克大鼠中，肝脏能荷（ATP + 1/2ADP）/（ATP + ADP + AMP）在2小时内迅速从0.857降至0.542，并在完成回输失血后迅速恢复至正常水平。休克2小时后，每克湿肝中腺嘌呤核苷酸总量从3.83微摩尔缓慢降至2.57微摩尔，在回输失血2小时后升至正常水平。在回输失血的同时，腹腔注射2毫克腺苷/100克体重、85毫克葡萄糖/100克体重和3.3单位胰岛素/100克体重，可增强能荷和腺嘌呤核苷酸水平的恢复。单独注射2毫克腺苷对恢复能荷无效。然而，无论是否添加胰岛素，给予超过6.7毫克腺苷/100克体重均可增强能荷和腺嘌呤核苷酸水平的恢复。
