Nat Cell Biol. 2011 Mar;13(3):199-201. doi: 10.1038/ncb0311-199.
Aneuploidy is one of the most prevalent phenotypes of human tumours, but the underlying cause of this phenomenon remains highly debated. Entosis, the invasion of a living cell into another cell's cytoplasm, is now shown to perturb cytokinesis and induce the formation of aneuploid cells.
非整倍体是人类肿瘤最常见的表型之一,但这一现象的根本原因仍存在高度争议。现在已经证明,侵入(entosis),即活细胞侵入另一个细胞的细胞质,会扰乱胞质分裂,并诱导非整倍体细胞的形成。