Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA.
Nat Rev Clin Oncol. 2011 Mar;8(3):184-7. doi: 10.1038/nrclinonc.2010.227.
Medicine will move from a reactive to a proactive discipline over the next decade--a discipline that is predictive, personalized, preventive and participatory (P4). P4 medicine will be fueled by systems approaches to disease, emerging technologies and analytical tools. There will be two major challenges to achieving P4 medicine--technical and societal barriers--and the societal barriers will prove the most challenging. How do we bring patients, physicians and members of the health-care community into alignment with the enormous opportunities of P4 medicine? In part, this will be done by the creation of new types of strategic partnerships--between patients, large clinical centers, consortia of clinical centers and patient-advocate groups. For some clinical trials it will necessary to recruit very large numbers of patients--and one powerful approach to this challenge is the crowd-sourced recruitment of patients by bringing large clinical centers together with patient-advocate groups.
在未来十年，医学将从反应性学科转变为主动性学科——即预测性、个性化、预防性和参与性（P4）医学。P4 医学将受到疾病系统方法、新兴技术和分析工具的推动。实现 P4 医学将面临两大挑战——技术和社会障碍，而社会障碍将是最具挑战性的。我们如何使患者、医生和医疗保健界成员与 P4 医学的巨大机遇保持一致？部分问题将通过创建新类型的战略伙伴关系来解决，包括患者、大型临床中心、临床中心联盟和患者倡导团体之间的伙伴关系。对于某些临床试验，有必要招募大量患者——通过将大型临床中心与患者倡导团体相结合，以众包方式招募患者是应对这一挑战的有力方法之一。
