Ximénez C, Hernández J, Melendro E I, Ramíro M
Subdivisión de Med de Med. Experimental, Facultad de Medicina, UNAM, D.F.
Arch Invest Med (Mex). 1990;21 Suppl 1:239-44.
Antiamebic antibody titers, were investigated in the feces and sera of 30 adults patients with intestinal amoebiasis, during the first two weeks of disease. Also, 29 control samples of healthy adult subjects were studied. The objective of this study was to determine if the local or systemic IgG, IgM or IgA levels were modified during the early stages of acute intestinal amoebiasis, for this purpose ELISA technique was use. Anti E. histolytica antibody titers in fecal samples of patients were not statistically different from titers detected in control samples, however in both groups IgA and IgM titers were higher than IgG levels. In serum samples IgG antibody titers were 4 fold higher in patients than in control group. With a P less than 0.006. In the case of IgM and IgA differences observed between the two groups studied were not statistically significant. Our results suggest that titration of coproantibodies against E. histolytica have not predictive value for intestinal amoebiasis in areas, were amoebiasis is a endemic disease. On the other hand we observed a discrete increase in IgG levels in the group of patients.
在疾病的前两周,对30例成年肠阿米巴病患者的粪便和血清中的抗阿米巴抗体滴度进行了研究。此外,还研究了29份健康成年受试者的对照样本。本研究的目的是确定在急性肠阿米巴病的早期阶段,局部或全身的IgG、IgM或IgA水平是否发生改变,为此采用了ELISA技术。患者粪便样本中的抗溶组织内阿米巴抗体滴度与对照样本中检测到的滴度无统计学差异,然而在两组中,IgA和IgM滴度均高于IgG水平。患者血清样本中的IgG抗体滴度比对照组高4倍,P值小于0.006。在IgM和IgA方面,所研究的两组之间观察到的差异无统计学意义。我们的结果表明,在阿米巴病为地方病的地区,针对溶组织内阿米巴的粪便抗体滴定对肠阿米巴病没有预测价值。另一方面,我们观察到患者组中IgG水平有轻微升高。