Wilkinson I, Cuschieri K S, Monaghan M, Salter D M, Wallace W A
Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, UK.
J R Coll Physicians Edinb. 2011 Mar;41(1):26-8. doi: 10.4997/JRCPE.2011.107.
Cytological features suggesting herpes simplex virus (HSV) infection in samples obtained at bronchoscopy have been described only very rarely in routinely processed samples. We report four cases where evidence of HSV infection was identified morphologically in samples processed using thin-layer techniques, with polymerase chain reaction confirmation of the presence of virus in three cases. We suggest that the increased morphological clarity provided by this technique for processing these cytology samples may result in the morphological features of viral infection being seen more frequently. Pathologists reporting such samples need to be aware of this possibility in order to avoid potential misinterpretations. In addition, however, respiratory and intensive care physicians unused to receiving cytology reports indicating 'HSV infection' need to be aware that the significance is uncertain and in most cases it is likely to indicate the reactivation of a latent infection.
在支气管镜检查时获取的样本中，提示单纯疱疹病毒（HSV）感染的细胞学特征在常规处理的样本中仅有极少的报道。我们报告了4例，这些病例在使用薄层技术处理的样本中通过形态学鉴定出了HSV感染的证据，其中3例经聚合酶链反应证实存在病毒。我们认为，这种处理这些细胞学样本的技术所提供的形态清晰度增加，可能会使病毒感染的形态学特征更频繁地被观察到。报告此类样本的病理学家需要意识到这种可能性，以避免潜在的错误解读。然而，此外，不习惯接收提示“HSV感染”的细胞学报告的呼吸科和重症监护医生需要意识到，其意义尚不确定，在大多数情况下，这可能表明潜伏感染的重新激活。
