Chair and Department of Family Medicine, The K. Marcinkowski Medical University, Poznań, Poland.
Endokrynol Pol. 2011 Jan-Feb;62(1):61-4.
In developed societies, the post-menopausal period covers approximately one third of a woman's life. The deficit of oestrogens observed during the post-menopausal period significantly affects the course of many metabolic processes, causing a number of diseases and in consequence diminishing quality of life. Among others, bones belong to oestrogen-dependent tissues. The deficit of the protective influence of oestrogens compromises the dynamic balance of the bone transformation process towards resorption, thus reducing bone mass and quality, while increasing the risk of low-energy fractures. In recent years, differing views on the application of oestrogen/gestagen therapy have reached the level of controversy. The results of numerous clinical studies are far from unequivocal, with the whole subject one of heated debate. It has been confirmed that hormonal therapy prevents bone quality deterioration, while opening a protective umbrella around the bone, reducing the risk of osteoporotic fractures. A rational approach to weighing possible advantages against possible risks and a thorough evaluation of a patient's health condition allows for optimal therapy selection.
在发达社会中，女性绝经后时期大约占其生命的三分之一。绝经后雌激素缺乏显著影响许多代谢过程的进程，导致多种疾病，并因此降低生活质量。骨组织属于雌激素依赖性组织。雌激素保护作用的缺乏破坏了骨转换过程中向吸收方向的动态平衡，从而降低骨量和质量，同时增加低能量骨折的风险。近年来，关于雌激素/孕激素治疗应用的不同观点已经达到争议的程度。许多临床研究的结果远非明确，整个主题都在激烈争论中。已经证实，激素治疗可以预防骨质量恶化，同时在骨周围形成保护伞，降低骨质疏松性骨折的风险。权衡可能的优点和可能的风险的合理方法以及对患者健康状况的彻底评估可以允许选择最佳的治疗方法。
