Reis L C, Ramalho M J, Antunes-Rodrigues J
Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1990;23(12):1335-8.
The present study was carried out to evaluate the participation of the serotonergic system (5-HT) in the modulation of the drinking response induced by water deprivation. Male Wistar rats implanted with a cannula in the 3rd ventricle were injected with the 5-HT1C/5-HT2 agonist 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) at doses of 0.5, 5, 25, 50 and 125 nmol/2 microliters. MK-212 induced a significant reduction (P less than or equal to 0.05) in water intake over a period of 300 min. This result indicates that the central 5-HT system plays an important role, probably at the level of the periventricular hypothalamus, in the modulation of drinking behavior induced by water deprivation.
本研究旨在评估血清素能系统（5-羟色胺，5-HT）在调节缺水诱导的饮水反应中的作用。将第三脑室植入套管的雄性Wistar大鼠分别注射剂量为0.5、5、25、50和125纳摩尔/2微升的5-HT1C/5-HT2激动剂6-氯-2-[1-哌嗪基]-吡嗪（MK-212）。MK-212在300分钟内使饮水量显著减少（P≤0.05）。该结果表明，中枢5-HT系统可能在室周下丘脑水平上，在调节缺水诱导的饮水行为中发挥重要作用。
