脑5-羟色胺能刺激减少由全身和中枢β-肾上腺素能给药诱导的水摄入量。

Brain serotoninergic stimulation reduces the water intake induced by systemic and central beta-adrenergic administration.

Reis L C, Ramalho M J, Antunes-Rodrigues J

Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.

Braz J Med Biol Res. 1992;25(5):529-36.

Abstract

This study was undertaken to determine if the stimulation of central serotoninergic receptors affects the thirst-inducing action of systemically or intracerebroventricularly (icv) injected isoproterenol. 2. Male Wistar rats weighing 220-300 g were used in groups of 10-14 animals each. Normally hydrated rats implanted with a delay cannula into the third ventricle were injected icv with the 5HT1C/5HT2 agonist MK212 (50 nmol/2 microliters) prior to administration of isoproterenol sc (330 micrograms/kg body weight) or icv (10 and 25 and 50 micrograms/2 microliters). 3. Icv injections of MK212 reduced the water intake induced by isoproterenol injected systemically (56%) and by the two lowest doses of isoproterenol injected icv (76 and 86%, respectively). 4. The results suggest that the central serotoninergic system modulates the central beta-adrenergic system involved in water intake. 5. Taken together with previous results showing that the activation of 5HT1C/5HT2 receptors promotes a reduction of the dipsogenic response evoked by water deprivation or by icv injection of angiotensin II or carbachol, the present data suggest that the central serotoninergic system plays a ubiquitous role in the modulation of water intake behavior.

摘要

本研究旨在确定刺激中枢5-羟色胺能受体是否会影响全身或脑室内注射异丙肾上腺素的致渴作用。2. 使用体重220 - 300克的雄性Wistar大鼠，每组10 - 14只动物。将延迟套管植入第三脑室的正常补水大鼠，在皮下注射异丙肾上腺素（330微克/千克体重）或脑室内注射（10、25和50微克/2微升）之前，先脑室内注射5HT1C/5HT2激动剂MK212（50纳摩尔/2微升）。3. 脑室内注射MK212可减少全身注射异丙肾上腺素诱导的水摄入量（56%）以及脑室内注射两种最低剂量异丙肾上腺素诱导的水摄入量（分别为76%和86%）。4. 结果表明，中枢5-羟色胺能系统调节参与水摄入的中枢β-肾上腺素能系统。5. 结合先前的结果表明，5HT1C/5HT2受体的激活促进了由缺水或脑室内注射血管紧张素II或卡巴胆碱引起的饮水反应的降低，目前的数据表明，中枢5-羟色胺能系统在调节水摄入行为中起普遍作用。