University of Illinois Fire Service Institute, Champaign, Illinois 61820, USA.
Prehosp Emerg Care. 2011 Apr-Jun;15(2):233-9. doi: 10.3109/10903127.2010.545477.
The leading cause of line-of-duty death among firefighters is sudden cardiac events. Platelets play a critical role in the formation of an occlusive thrombus during an ischemic event.
The purpose of this study was to examine the acute effect of firefighting on platelet number and aggregability.
Apparently healthy male firefighters (N = 114; age 29.4 ± 7.8 years) participated in 18 minutes of simulated firefighting activity in a training structure that contained live fires. Blood samples were obtained before and after simulated firefighting activity and analyzed for complete blood cell count (CBC), chemistry, and platelet number and function. Platelet function was measured using a PFA-100 analyzer to assess platelet aggregability.
As expected, performing firefighting activity resulted in significant increases in heart rate (75 b·min(-1)) and core temperature (0.7 °C), and significant changes in blood chemistry values. The most important finding in this study is that 18 minutes of simulated firefighting caused a 24% increase in platelet number and a significant increase in platelet aggregability.
Firefighting resulted in a significant increase in platelet number and aggregability, indicating that even short bouts of firefighting can increase thrombotic potential in apparently healthy firefighters.
消防员因公殉职的首要原因是心源性猝死。血小板在缺血性事件中形成闭塞性血栓的过程中起着至关重要的作用。
本研究旨在探讨消防活动对血小板数量和聚集性的急性影响。
本研究纳入了 114 名健康的男性消防员（年龄 29.4±7.8 岁），他们参与了在一个包含真火的训练结构中进行的 18 分钟模拟消防活动。在模拟消防活动前后采集血样，进行全血细胞计数（CBC）、血液化学和血小板数量及功能分析。使用 PFA-100 分析仪测量血小板功能，评估血小板聚集性。
正如预期的那样，进行消防活动会导致心率（75 次/分钟）和核心体温（升高 0.7°C）显著增加，血液化学值也发生显著变化。本研究最重要的发现是，18 分钟的模拟消防活动导致血小板数量增加 24%，血小板聚集性显著增加。
消防活动导致血小板数量和聚集性显著增加，表明即使是短暂的消防活动也会增加健康消防员的血栓形成倾向。
