Department of Environmental Studies, Emory University, Atlanta, GA 30322, USA.
Trans R Soc Trop Med Hyg. 2011 Apr;105(4):226-31. doi: 10.1016/j.trstmh.2011.01.001. Epub 2011 Mar 1.
Spleen rates (SR) have been traditionally used to estimate the burden of malaria transmission. Results are presented from 51 surveys, which measured SR and parasite rates (PR) in 29,962 individuals in the archipelago of Vanuatu. Indices for spleen size computed with multivariate statistical tools outperformed the WHO average spleen index and showed that spleen sizes in a population can track shifts in malaria transmission. In general, a positive linear relationship between Plasmodium spp. PR and SR was found for the archipelago. In the context of malaria elimination and for the specific setting of this study we found that spleen examination is a useful tool in post-malaria elimination surveillance. Finally, results highlight the value of measuring spleen sizes to rapidly assess the impact of intervention packages aimed at malaria elimination or control.
脾率（SR）一直被用来估计疟疾传播的负担。本文介绍了在瓦努阿图群岛进行的 51 项调查结果，这些调查共测量了 29962 人的脾率和寄生虫率（PR）。使用多变量统计工具计算的脾大小指数优于世界卫生组织的平均脾指数，并表明人群中的脾大小可以跟踪疟疾传播的变化。一般来说，在群岛中发现了疟原虫 PR 和 SR 之间存在正线性关系。在消除疟疾的背景下，以及在本研究的特定背景下，我们发现脾脏检查是消除后疟疾监测的有用工具。最后，结果强调了测量脾大小以快速评估旨在消除或控制疟疾的干预措施包的影响的价值。
