Miyajima Miho, Ohta Katsuya, Hara Keiko, Iino Hiroko, Maehara Taketoshi, Hara Minoru, Matsuura Masato, Matsushima Eisuke
Section of Liaison Psychiatry and Palliative Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; Hara Clinic, Kanagawa, Japan.
Section of Liaison Psychiatry and Palliative Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; Onda-daini Hospital, Chiba, Japan; Section of Life Sciences and Biofunctional Informatics, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Epilepsy Res. 2011 May;94(3):149-57. doi: 10.1016/j.eplepsyres.2011.01.009. Epub 2011 Mar 1.
Auditory processing abnormalities in temporal lobe epilepsy (TLE) were assessed by investigating mismatch negativity (MMN) in a group of 20 TLE patients and 20 healthy control subjects. MMN is an event-related potential (ERP) component that reflects pre-attentive sensory memory function. A passive oddball paradigm using frequency changes in sinusoidal tones was employed to evoke MMN. MMN at frontocentral sites was enhanced in TLE patients relative to controls, while mismatch signals at mastoid sites (i.e., mismatch positivity; MMP) did not differ between the two groups. In the MMP temporal range, greater positivity at mastoid sites in response to standard stimuli was observed in TLE patients than in controls. Both MMN and MMP were significantly delayed in the TLE group. These findings demonstrate that TLE patients have impaired pre-attentive processing of pure-tone sounds. Enhanced frontocentral MMN may reflect hyperexcitability of the frontal lobes in compensation for dysfunction of the temporal lobes. Larger positivity at the mastoids in response to standard stimuli may be attributed to poor neuronal adaptation in the temporal lobe. Taken together, results suggest that evaluation of MMN/P is a useful physiological tool for identifying pre-attentive auditory memory dysfunction in TLE.
通过对20名颞叶癫痫（TLE）患者和20名健康对照者进行失匹配负波（MMN）检测，评估颞叶癫痫患者的听觉处理异常情况。MMN是一种事件相关电位（ERP）成分，反映了前注意感觉记忆功能。采用一种使用正弦音调频率变化的被动oddball范式来诱发MMN。与对照组相比，TLE患者额中央部位的MMN增强，而两组在乳突部位的失匹配信号（即失匹配正波；MMP）无差异。在MMP的时间范围内，TLE患者对标准刺激的乳突部位阳性反应比对照组更强。TLE组的MMN和MMP均显著延迟。这些发现表明，TLE患者对纯音的前注意处理受损。额中央MMN增强可能反映额叶的兴奋性过高，以代偿颞叶功能障碍。对标准刺激乳突部位更大的阳性反应可能归因于颞叶神经元适应性差。综上所述，结果表明MMN/P评估是识别TLE患者前注意听觉记忆功能障碍的一种有用的生理工具。
