Department of Life Sciences and Biofunctional Informatics, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
Epilepsy Behav. 2012 Mar;23(3):335-41. doi: 10.1016/j.yebeh.2012.01.019. Epub 2012 Feb 28.
The mismatch negativity (MMN) is an electrophysiological trace of change detection, measured by electroencephalography (EEG), and is a reliable marker for pre-attentive auditory sensory memory. We used a phonetic oddball paradigm in patients with temporal lobe epilepsy (TLE) to elicit the MMN response at fronto-central sites and the mismatch positivity (MMP) response at mastoid sites. The MMN in 26 patients was compared with that of 26 age- and gender-matched healthy control participants. Electroencephalography responses were recorded during the presentation of speech sounds: the vowels 'a' and 'o' in alternation. Average waveforms were obtained for standard and deviant trials. We found that the MMP response at bilateral mastoid sites was reduced, whereas the MMN response at fronto-central sites did not change significantly. These results support the view that the MMN is generated by separable sources in the frontal and temporal lobes and that these sources are differentially affected by TLE.
失匹配负波（MMN）是一种通过脑电图（EEG）测量的变化检测的电生理痕迹，是前注意听觉感觉记忆的可靠标志物。我们使用颞叶癫痫（TLE）患者的语音Oddball 范式，在额中央部位诱发出 MMN 反应，在乳突部位诱发出 MMN 正波（MMP）反应。将 26 名患者的 MMN 与 26 名年龄和性别匹配的健康对照组进行比较。在呈现语音时记录脑电图反应：元音“a”和“o”交替出现。为标准和偏差试验获得平均波形。我们发现双侧乳突部位的 MMP 反应降低，而额中央部位的 MMN 反应没有明显变化。这些结果支持 MMN 是由额颞叶中可分离的来源产生的观点，并且这些来源受 TLE 的影响不同。
