通过脑脊液中 CXCL13 的水平来区分莱姆神经Borreliosis 与其他神经炎症性疾病。
Discriminating Lyme neuroborreliosis from other neuroinflammatory diseases by levels of CXCL13 in cerebrospinal fluid.
机构信息
Department of Medical Microbiology, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, Netherlands.
出版信息
J Clin Microbiol. 2011 May;49(5):2027-30. doi: 10.1128/JCM.00084-11. Epub 2011 Mar 2.
Abstract
CXCL13 in cerebrospinal fluid (CSF) could be an important component for diagnosing Lyme neuroborreliosis (LNB). Levels of intrathecal CXCL13 were determined for 58 LNB patients and 210 controls; sensitivity was 88% and specificity was 89% (cutoff, 250 pg of CXCL13/ml of CSF). Elevated levels of CXCL13 can aid in the diagnosis of LNB, but levels should be interpreted with care.
摘要
脑脊液（CSF）中的 CXCL13 可能是诊断莱姆神经Borreliosis（LNB）的一个重要组成部分。对 58 例 LNB 患者和 210 例对照者的 CSF 中 CXCL13 水平进行了测定；其灵敏度为 88%，特异性为 89%（临界值为 CSF 中 250pg/ml 的 CXCL13）。CXCL13 水平升高有助于诊断 LNB，但应谨慎解读。
相似文献
1
Discriminating Lyme neuroborreliosis from other neuroinflammatory diseases by levels of CXCL13 in cerebrospinal fluid.通过脑脊液中 CXCL13 的水平来区分莱姆神经Borreliosis 与其他神经炎症性疾病。
J Clin Microbiol. 2011 May;49(5):2027-30. doi: 10.1128/JCM.00084-11. Epub 2011 Mar 2.
2
Evaluation of two assays for CXCL13 analysis in cerebrospinal fluid for laboratory diagnosis of Lyme neuroborreliosis.评估两种用于脑脊液中CXCL13分析的检测方法在莱姆病神经伯氏疏螺旋体病实验室诊断中的应用。
APMIS. 2016 Nov;124(11):985-990. doi: 10.1111/apm.12596. Epub 2016 Sep 20.
3
Cerebrospinal Fluid B-lymphocyte Chemoattractant CXCL13 in the Diagnosis of Acute Lyme Neuroborreliosis in Children.脑脊液B淋巴细胞趋化因子CXCL13在儿童急性莱姆病性神经伯氏疏螺旋体病诊断中的作用
Pediatr Infect Dis J. 2017 Dec;36(12):e286-e292. doi: 10.1097/INF.0000000000001669.
4
CXCL13 concentrations in cerebrospinal fluid of patients with Lyme neuroborreliosis and other neurological disorders determined by Luminex and ELISA.采用 Luminex 和 ELISA 法测定莱姆神经Borreliosis 患者和其他神经系统疾病患者脑脊液中 CXCL13 浓度。
Ticks Tick Borne Dis. 2018 Jul;9(5):1137-1142. doi: 10.1016/j.ttbdis.2018.04.008. Epub 2018 Apr 20.
5
The chemokine CXCL13 in cerebrospinal fluid in children with Lyme neuroborreliosis.脑脊髓液中趋化因子 CXCL13 在儿童莱姆神经Borreliosis 中的作用。
Eur J Clin Microbiol Infect Dis. 2018 Oct;37(10):1983-1991. doi: 10.1007/s10096-018-3334-3. Epub 2018 Aug 6.
6
CXCL13 and neopterin concentrations in cerebrospinal fluid of patients with Lyme neuroborreliosis and other diseases that cause neuroinflammation.莱姆病神经伯氏疏螺旋体病患者及其他引起神经炎症疾病患者脑脊液中CXCL13和新蝶呤的浓度。
J Neuroinflammation. 2014 Jun 11;11:103. doi: 10.1186/1742-2094-11-103.
7
CXCL13 may improve diagnosis in early neuroborreliosis with atypical laboratory findings.CXCL13 可能有助于改善伴有非典型实验室检查结果的早期神经莱姆病的诊断。
BMC Infect Dis. 2012 Dec 10;12:344. doi: 10.1186/1471-2334-12-344.
8
Cerebrospinal fluid CXCL13 as a diagnostic marker of neuroborreliosis in children: a retrospective case-control study.脑脊液 CXCL13 作为儿童神经莱姆病的诊断标志物：一项回顾性病例对照研究。
J Neuroinflammation. 2017 Aug 31;14(1):173. doi: 10.1186/s12974-017-0948-9.
9
CXCL13 in laboratory diagnosis of Lyme neuroborreliosis-the performance of the recomBead and ReaScan CXCL13 assays in human cerebrospinal fluid samples.CXCL13 在莱姆神经Borreliosis 实验室诊断中的应用——recomBead 和 ReaScan CXCL13 检测试剂盒在人脑脊液样本中的性能。
Eur J Clin Microbiol Infect Dis. 2022 Jan;41(1):175-179. doi: 10.1007/s10096-021-04350-y. Epub 2021 Oct 9.
10
Cerebrospinal fluid chemokine CXCL13 in the diagnosis of neuroborreliosis in children.脑脊液趋化因子CXCL13在儿童神经莱姆病诊断中的应用
Scand J Infect Dis. 2013 Jul;45(7):526-30. doi: 10.3109/00365548.2013.776700. Epub 2013 Mar 22.
引用本文的文献
1
Encephalitis: Predictive Role of Clinical and Diagnostic Data on Outcome-A Monocentric Study.脑炎：临床及诊断数据对预后的预测作用——一项单中心研究
Life (Basel). 2025 Aug 19;15(8):1313. doi: 10.3390/life15081313.
2
Cerebrospinal fluid protein profiling of inflammatory and neurobiological markers in Lyme neuroborreliosis.莱姆病神经伯氏疏螺旋体病中炎症和神经生物学标志物的脑脊液蛋白质谱分析
Sci Rep. 2025 Jun 20;15(1):20190. doi: 10.1038/s41598-025-06146-y.
3
Prognostic Value of CXCL13, CCL11, and CCL20 Chemokines in Multiple Sclerosis.CXCL13、CCL11和CCL20趋化因子在多发性硬化症中的预后价值
Biomedicines. 2024 Dec 27;13(1):40. doi: 10.3390/biomedicines13010040.
4
CXCL13 as a Biomarker: Background and Utility in Multiple Sclerosis.CXCL13作为一种生物标志物：在多发性硬化症中的背景与应用
Biomolecules. 2024 Nov 30;14(12):1541. doi: 10.3390/biom14121541.
5
CXCL13 as a biomarker in the diagnostics of European lyme Neuroborreliosis - A prospective multicentre study in Austria.CXCL13作为欧洲莱姆病神经疏螺旋体病诊断中的生物标志物——奥地利一项前瞻性多中心研究
J Cent Nerv Syst Dis. 2024 May 2;16:11795735241247026. doi: 10.1177/11795735241247026. eCollection 2024.
6
CXCL13 in Cerebrospinal Fluid: Clinical Value in a Large Cross-Sectional Study.脑脊液中 CXCL13 的检测：一项大型横断面研究的临床价值。
Int J Mol Sci. 2023 Dec 28;25(1):425. doi: 10.3390/ijms25010425.
7
Lyme borreliosis diagnosis: state of the art of improvements and innovations.莱姆病诊断：改进和创新的最新进展。
BMC Microbiol. 2023 Aug 1;23(1):204. doi: 10.1186/s12866-023-02935-5.
8
Cerebrospinal Fluid CXCL13 as Candidate Biomarker of Intrathecal Immune Activation, IgG Synthesis and Neurocognitive Impairment in People with HIV.脑脊液 CXCL13 作为 HIV 感染者鞘内免疫激活、IgG 合成和神经认知障碍的候选生物标志物。
J Neuroimmune Pharmacol. 2023 Jun;18(1-2):169-182. doi: 10.1007/s11481-023-10066-x. Epub 2023 May 11.
9
The Brave New World of Early Treatment of Multiple Sclerosis: Using the Molecular Biomarkers CXCL13 and Neurofilament Light to Optimize Immunotherapy.多发性硬化早期治疗的全新世界：利用分子生物标志物CXCL13和神经丝轻链优化免疫治疗
Biomedicines. 2022 Aug 28;10(9):2099. doi: 10.3390/biomedicines10092099.
10
The CXCL13/CXCR5 Immune Axis in Health and Disease-Implications for Intrathecal B Cell Activities in Neuroinflammation.CXCL13/CXCR5 免疫轴在健康和疾病中的作用-对神经炎症中鞘内 B 细胞活性的影响。
Cells. 2022 Aug 25;11(17):2649. doi: 10.3390/cells11172649.
本文引用的文献
1
Diagnostic performance of cerebrospinal fluid chemokine CXCL13 and antibodies to the C6-peptide in Lyme neuroborreliosis.脑脊液趋化因子 CXCL13 和抗 C6 肽抗体在莱姆神经Borreliosis 中的诊断性能。
J Infect. 2011 Feb;62(2):149-58. doi: 10.1016/j.jinf.2010.11.005. Epub 2010 Nov 16.
2
Elevation of serum CXCL13 in SLE as well as in sepsis.血清 CXCL13 在 SLE 及脓毒症中的升高。
Lupus. 2011 Apr;20(5):507-11. doi: 10.1177/0961203310383301. Epub 2010 Nov 15.
3
Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS.活动性多发性硬化症患者脑脊液中趋化因子CXCL13浓度升高。
Neurology. 2009 Dec 8;73(23):2003-10. doi: 10.1212/WNL.0b013e3181c5b457.
4
The chemokine CXCL13 in acute neuroborreliosis.急性神经莱姆病中的趋化因子 CXCL13。
J Neurol Neurosurg Psychiatry. 2010 Aug;81(8):929-33. doi: 10.1136/jnnp.2009.195438. Epub 2009 Dec 3.
5
EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis.EFNS 指南：欧洲莱姆神经Borreliosis 的诊断和管理。
Eur J Neurol. 2010 Jan;17(1):8-16, e1-4. doi: 10.1111/j.1468-1331.2009.02862.x. Epub 2009 Nov 23.
6
B-cell-attracting chemokine CXCL13 as a marker of disease activity and renal involvement in systemic lupus erythematosus (SLE).B 细胞趋化因子 CXCL13 作为系统性红斑狼疮 (SLE) 疾病活动和肾脏受累的标志物。
Nephrol Dial Transplant. 2009 Dec;24(12):3708-12. doi: 10.1093/ndt/gfp343. Epub 2009 Jul 13.
7
Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection.慢性HIV-1感染期间B细胞中受体-配体对CXCR5/CXCL13的表达改变。
Blood. 2008 Dec 1;112(12):4401-10. doi: 10.1182/blood-2008-02-140426. Epub 2008 Sep 9.
8
CSF B--lymphocyte chemoattractant (CXCL13) in the early diagnosis of acute Lyme neuroborreliosis.脑脊液B淋巴细胞趋化因子（CXCL13）在急性莱姆病神经伯氏疏螺旋体病早期诊断中的作用
J Neurol. 2008 May;255(5):732-7. doi: 10.1007/s00415-008-0785-y. Epub 2008 Mar 17.
9
Relevance of the antibody index to diagnose Lyme neuroborreliosis among seropositive patients.抗体指数在血清学阳性患者中对莱姆病神经伯氏疏螺旋体病诊断的相关性。
Neurology. 2007 Sep 4;69(10):953-8. doi: 10.1212/01.wnl.0000269672.17807.e0.
10
Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection.在HIV感染期间，稳态B细胞趋化因子CXCL13的血清水平会升高。
J Interferon Cytokine Res. 2005 Nov;25(11):702-6. doi: 10.1089/jir.2005.25.702.
Zotero 插件