Hematology Division, University of Utah, 30 North 1900 East, Salt Lake City, UT 84132, USA.
Am J Physiol Cell Physiol. 2011 Jun;300(6):C1215-22. doi: 10.1152/ajpcell.00044.2011. Epub 2011 Mar 2.
Our understanding of organismal responses to hypoxia has stemmed from studies of erythropoietin regulation by hypoxia that led to the discovery of the master regulator of the hypoxic response, i.e., hypoxia-inducible factor (HIF). This is a transcription factor that is now known to induce the expression of a battery of genes in response to hypoxia. HIF-1 and HIF-2 regulate many genes that are involved in erythropoiesis and iron metabolism, which are essential for tissue oxygen delivery.
我们对机体缺氧反应的认识源于对缺氧条件下促红细胞生成素调节的研究，该研究发现了缺氧反应的主要调节因子，即缺氧诱导因子（HIF）。这是一种转录因子，现在已知它可以在缺氧条件下诱导一系列基因的表达。HIF-1 和 HIF-2 调节许多参与红细胞生成和铁代谢的基因，这些基因对于组织供氧至关重要。
