Kyoto University School of Public Health, Sakyo-ku, Kyoto, Japan.
J Epidemiol. 2011;21(3):176-83. doi: 10.2188/jea.je20100138. Epub 2011 Feb 26.
Few studies have examined whether declines over time in hand-grip strength (HGS) and fast walking speed (FWS) differ by sex and age among non-Western community-dwelling older adults. This study aimed to quantify changes in HGS and FWS over the 6-year period from 1994 to 2000 and examine whether these changes differed by sex and baseline age among older individuals in a Japanese community.
We conducted a community-based prospective cohort study. The participants were 513 nondisabled men and women aged 67 to 91 years at the 1994 survey. Independent variables regarding time since baseline, in addition to various time-dependent and time-independent covariates, were obtained in 1994, 1996, 1998, and 2000. The outcome variables were HGS and FWS assessed at each survey. All data on independent and dependent variables that were collected at each survey were simultaneously analyzed using a linear mixed-effects model.
The linear mixed-effects model revealed significant declines in both HGS (-0.70 kg/year, P < 0.001) and FWS (-0.027 m/sec/year, P < 0.001) among nondisabled older participants who had analyzable data in any survey during the 6-year period. Sex was significantly associated with the rate of decline in HGS (P < 0.001), but not FWS (P = 0.211).
In this analysis of nondisabled older Japanese, a mixed-effects model confirmed a significant effect of aging on declines in HGS and FWS and showed that men had a significantly steeper decline in HGS than did women during a 6-year period.
很少有研究调查过非西方社区居住的老年人群中,手握力(HGS)和快速步行速度(FWS)随时间的下降是否因性别和年龄而异。本研究旨在量化 1994 年至 2000 年 6 年间 HGS 和 FWS 的变化,并检查这些变化在日本社区的老年个体中是否因性别和基线年龄而异。
我们进行了一项基于社区的前瞻性队列研究。参与者是 1994 年调查时年龄在 67 至 91 岁之间的 513 名非残疾男性和女性。除了各种随时间变化和随时间不变的协变量外,我们还在 1994 年、1996 年、1998 年和 2000 年获得了关于自基线以来时间的独立变量。在每次调查中评估 HGS 和 FWS 的结果变量。在每次调查中收集的所有关于独立和依赖变量的数据均使用线性混合效应模型进行了同时分析。
线性混合效应模型显示,在 6 年期间任何一次调查中都有可分析数据的非残疾老年参与者中,HGS(-0.70 公斤/年,P<0.001)和 FWS(-0.027 米/秒/年,P<0.001)均显著下降。性别与 HGS 下降率显著相关(P<0.001),但与 FWS 无关(P=0.211)。
在这项对非残疾日本老年人的分析中,混合效应模型证实了衰老对手握力和步行速度下降的显著影响,并表明男性在 6 年内 HGS 的下降速度明显快于女性。