Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA.
Curr Opin Allergy Clin Immunol. 2011 Apr;11(2):144-9. doi: 10.1097/ACI.0b013e3283445950.
The purpose of this review is to consider the collective influence of factors affecting recurrent wheezing in young children.
Specific allergen sensitization, upper respiratory infections, genetic polymorphisms and environmental factors have collectively been reported in the prevalence of and induction of recurrent wheezing in young children. Two examples of environmental factors are diet and exposure to air pollution, both of which are potentially modifiable. Recent investigations provide evidence that a 'Mediterranean diet' and a diet that emphasizes polyunsaturated fatty acids during pregnancy and early infancy, as well as breastfeeding, may be protective for wheezing, and that exposure to traffic-related pollution may be an independent factor in the incidence of wheezing in young children.
Recent studies of early childhood wheezing demonstrate a potentially protective effect of diet and exposure to air pollution as a significant risk factor. An evaluation of collective factors influencing the presence of disease may help to broaden the clinical assessment and give parents and physicians the opportunity to potentially modify circumstances that promote the incidence of recurrent wheezing in infants and preschool aged children.
本综述旨在探讨影响幼儿反复喘息的各种因素的综合影响。
特定过敏原致敏、上呼吸道感染、遗传多态性和环境因素均与幼儿反复喘息的发生和诱导有关。饮食和空气污染暴露是两个潜在的可改变的环境因素的例子。最近的研究提供了证据,表明“地中海饮食”和强调在妊娠和婴儿早期摄入多不饱和脂肪酸以及母乳喂养的饮食可能对喘息有保护作用,而接触交通相关污染可能是幼儿喘息发生的一个独立因素。
最近对幼儿喘息的研究表明,饮食和空气污染暴露作为一个重要的危险因素,可能具有潜在的保护作用。评估影响疾病存在的综合因素可能有助于拓宽临床评估,并为家长和医生提供机会,可能改变促进婴儿和学龄前儿童反复喘息发生的环境。