• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

胆囊收缩素对分离血管灌注大鼠结肠运动的作用机制。

Mechanism of action of cholecystokinin on colonic motility in isolated, vascularly perfused rat colon.

机构信息

Department of Internal Medicine, Cheongju St. Mary's Hospital, Cheongju, Chungcheongbuk-do, Korea.

出版信息

J Neurogastroenterol Motil. 2011 Jan;17(1):73-81. doi: 10.5056/jnm.2011.17.1.73. Epub 2011 Jan 26.

DOI:10.5056/jnm.2011.17.1.73
PMID:21369495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3042223/
Abstract

BACKGROUND/AIMS: It is generally believed that cholecystokinin (CCK) stimulates colonic motility, although there are controversial reports. It has also been suggested that postprandial peptide YY (PYY) release is CCK-dependent. Using a totally isolated, vascularly perfused rat colon, we investigated: (1) the roles of CCK and PYY on colonic motility, (2) to determine if CCK modulates PYY release from the colon to influence the motility and (3) to clarify whether the action of CCK and PYY on colonic motility is mediated via the influence of cholinergic input.

METHODS

An isolated whole rat colon was used. Luminal pressure was monitored via microtip catheter pressure transducers from proximal and distal colon. After a control period, CCK-8 or PYY was administerd intraarterially with or without an anti-PYY serum, loxiglumide or atropine at 12, 60 and 240 pM. Each dose was given for a period of 15-minute and the contractile response was expressed as % changes over basal. PYY concentration in the portal effluent was determined by radioimmunoassay.

RESULTS

Exogenous CCK-8 increased colonic motility which paralleled the increase in PYY release in the portal effluent. Exogenous PYY also significantly increased colonic motility although it was less potent than CCK. The stimulating effect of CCK-8 was significantly inhibited by an anti-PYY serum, and was completely abolished by loxiglumide, and almost completely abolished by atropine.

CONCLUSIONS

CCK increases colonic motility via CCK(1) receptor and it is mediated partly by PYY. Cholinergic input is required for the increased motility by either PYY or CCK.

摘要

背景/目的：人们普遍认为胆囊收缩素（CCK）会刺激结肠蠕动，尽管也有一些有争议的报告。也有人认为餐后肽 YY（PYY）的释放是 CCK 依赖性的。本研究使用完全分离的血管灌注大鼠结肠，研究了：（1）CCK 和 PYY 对结肠运动的作用，（2）确定 CCK 是否调节 PYY 从结肠释放以影响运动，以及（3）阐明 CCK 和 PYY 对结肠运动的作用是否通过影响胆碱能输入来介导。

方法

使用分离的整个大鼠结肠。通过微tip 导管压力换能器从近端和远端结肠监测腔内腔压力。在对照期后，以 12、60 和 240 pM 的剂量经动脉内给予 CCK-8 或 PYY，同时或不给予抗 PYY 血清、loxiglumide 或阿托品。每个剂量给药 15 分钟，收缩反应表示为相对于基础的百分比变化。通过放射免疫测定法测定门静脉流出物中的 PYY 浓度。

结果

外源性 CCK-8 增加了结肠蠕动，与门静脉流出物中 PYY 释放的增加平行。外源性 PYY 也显著增加了结肠蠕动，尽管其效力低于 CCK。CCK-8 的刺激作用被抗 PYY 血清显著抑制，loxiglumide 完全抑制，阿托品几乎完全抑制。

结论

CCK 通过 CCK（1）受体增加结肠蠕动，部分通过 PYY 介导。无论是 PYY 还是 CCK，增加的运动都需要胆碱能输入。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/27c80f5ba727/jnm-17-73-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/8aac2669580b/jnm-17-73-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/412a3f68e626/jnm-17-73-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/56b06021d606/jnm-17-73-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/6314e80aace6/jnm-17-73-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/902bfe0b5df2/jnm-17-73-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/9a8c456ae120/jnm-17-73-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/d9de96ed9761/jnm-17-73-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/5f2cd4e98a15/jnm-17-73-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/29509066c85c/jnm-17-73-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/27c80f5ba727/jnm-17-73-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/8aac2669580b/jnm-17-73-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/412a3f68e626/jnm-17-73-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/56b06021d606/jnm-17-73-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/6314e80aace6/jnm-17-73-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/902bfe0b5df2/jnm-17-73-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/9a8c456ae120/jnm-17-73-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/d9de96ed9761/jnm-17-73-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/5f2cd4e98a15/jnm-17-73-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/29509066c85c/jnm-17-73-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1a/3042223/27c80f5ba727/jnm-17-73-g010.jpg

相似文献

1
Mechanism of action of cholecystokinin on colonic motility in isolated, vascularly perfused rat colon.胆囊收缩素对分离血管灌注大鼠结肠运动的作用机制。
J Neurogastroenterol Motil. 2011 Jan;17(1):73-81. doi: 10.5056/jnm.2011.17.1.73. Epub 2011 Jan 26.
2
Cholecystokinin mediation of colonic absorption via peptide YY: foregut-hindgut axis.胆囊收缩素通过肽YY介导结肠吸收：前肠-后肠轴
World J Surg. 1996 Feb;20(2):221-7. doi: 10.1007/s002689900034.
3
Regulation of glucagon-like peptide-1-(7-36) amide, peptide YY, and neurotensin secretion by neurotransmitters and gut hormones in the isolated vascularly perfused rat ileum.神经递质和胃肠激素对离体血管灌注大鼠回肠中胰高血糖素样肽-1-（7-36）酰胺、肽YY和神经降压素分泌的调节
Endocrinology. 1995 Nov;136(11):5182-8. doi: 10.1210/endo.136.11.7588257.
4
Release of peptide YY by neurotransmitters and gut hormones in the isolated, vascularly perfused rat colon.神经递质和肠道激素在离体、血管灌注大鼠结肠中对肽YY的释放作用
Scand J Gastroenterol. 1995 Jun;30(6):568-74. doi: 10.3109/00365529509089791.
5
Luminal peptide YY-releasing factors in the isolated vascularly perfused rat colon.分离的血管灌注大鼠结肠中的肠腔肽YY释放因子。
J Endocrinol. 1996 Dec;151(3):421-9. doi: 10.1677/joe.0.1510421.
6
Cholecystokinin stimulates neuronal receptors to produce contraction of the canine colon.胆囊收缩素刺激神经元受体，引起犬结肠收缩。
Life Sci. 1989;44(8):533-42. doi: 10.1016/0024-3205(89)90615-2.
7
Postprandial peptide YY release is mediated by cholecystokinin.餐后肽YY的释放由胆囊收缩素介导。
Surg Gynecol Obstet. 1992 Aug;175(2):145-50.
8
Intestinal phase of human antro-pyloro-duodenal motility: cholinergic and CCK-mediated regulation.人类胃窦-幽门-十二指肠运动的肠期：胆碱能和胆囊收缩素介导的调节
Eur J Clin Invest. 1996 Jul;26(7):574-83. doi: 10.1046/j.1365-2362.1996.1790522.x.
9
Atropine and naloxone block the colonic contraction elicited by cholecystokinin and pentagastrin.阿托品和纳洛酮可阻断由胆囊收缩素和五肽胃泌素引起的结肠收缩。
Acta Physiol Scand. 1985 May;124(1):25-33. doi: 10.1111/j.1748-1716.1985.tb07628.x.
10
Corticotropin-releasing factor stimulates colonic motility muscarinic receptors in the rat.促肾上腺皮质激素释放因子刺激大鼠结肠运动的毒蕈碱受体。
World J Gastroenterol. 2017 Jun 7;23(21):3825-3831. doi: 10.3748/wjg.v23.i21.3825.

引用本文的文献

1
CCK-1 and CCK-2 receptor agonism do not stimulate GLP-1 and neurotensin secretion in the isolated perfused rat small intestine or GLP-1 and PYY secretion in the rat colon.胆囊收缩素-1 和胆囊收缩素-2 受体激动剂不能刺激离体灌注大鼠小肠中的 GLP-1 和神经降压素分泌，也不能刺激大鼠结肠中的 GLP-1 和 PYY 分泌。
Physiol Rep. 2020 Jan;8(2):e14352. doi: 10.14814/phy2.14352.

本文引用的文献

1
Involvement of endogenous CCK and CCK1 receptors in colonic motor function.内源性胆囊收缩素及胆囊收缩素1受体在结肠运动功能中的作用
Br J Pharmacol. 2004 Apr;141(8):1275-84. doi: 10.1038/sj.bjp.0705769.
2
Release of peptide YY by fat in the proximal but not distal gut depends on an atropine-sensitive cholinergic pathway.近端而非远端肠道中的脂肪对肽YY的释放取决于一条对阿托品敏感的胆碱能途径。
Regul Pept. 2004 Jan 15;117(1):73-6. doi: 10.1016/j.regpep.2003.10.008.
3
Multiple regulation of peptide YY secretion in the digestive tract.消化道中肽YY分泌的多重调节。
Peptides. 2002 Feb;23(2):279-90. doi: 10.1016/s0196-9781(01)00609-x.
4
Localization and characterization of neuropeptide receptors in human colon.人结肠中神经肽受体的定位与特性分析
Naunyn Schmiedebergs Arch Pharmacol. 2001 Oct;364(4):291-304. doi: 10.1007/s002100100454.
5
Colonic motility abnormality in patients with irritable bowel syndrome exhibiting abdominal pain and diarrhea.患有腹痛和腹泻的肠易激综合征患者的结肠运动异常。
Am J Gastroenterol. 2001 May;96(5):1499-506. doi: 10.1111/j.1572-0241.2001.03804.x.
6
Release of distal gut peptide YY (PYY) by fat in proximal gut depends on CCK.近端肠道中的脂肪促使远端肠道释放肽YY（PYY）取决于胆囊收缩素（CCK）。
Peptides. 2000 Oct;21(10):1561-3. doi: 10.1016/s0196-9781(00)00312-0.
7
International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors.国际药理学联合会。二十一。胆囊收缩素受体的结构、分布及功能。
Pharmacol Rev. 1999 Dec;51(4):745-81.
8
Cholecystokinin cells.胆囊收缩素细胞
Annu Rev Physiol. 1997;59:221-42. doi: 10.1146/annurev.physiol.59.1.221.
9
Studies on the viability of the isolated vascularly perfused rat colon.离体血管灌注大鼠结肠存活能力的研究。
Digestion. 1996;57(5):349-55. doi: 10.1159/000201356.
10
Choline acetyltransferase immunoreactivity in the human small and large intestine.人小肠和大肠中的胆碱乙酰转移酶免疫反应性
Gastroenterology. 1996 Aug;111(2):401-8. doi: 10.1053/gast.1996.v111.pm8690205.