Department of Chemistry, The University of Alabama, Box 870336, Tuscaloosa, AL 35487-0336, USA.
Biol Trace Elem Res. 2011 Dec;143(3):1666-72. doi: 10.1007/s12011-011-9002-4. Epub 2011 Mar 3.
Chromium(III) picolinate, [Cr(pic)(3)], is a commonly used nutritional supplement in humans, which has also been approved for use in animals. Health concerns have arisen over the use of [Cr(pic)(3)]. At high [Cr(pic)(3)] doses, developmental toxicity tests in female mice have shown a higher litter incidence of split cervical arch in exposed fetuses, but this was not consistently reproducible. In the current study, male CD-1 mice were used to further assess the potential for reproductive or developmental toxicity. Four weeks prior to mating, the males were fed a diet providing 200 mg/kg/day [Cr(pic)(3)] for comparison with untreated controls. Females were not treated. Each male was mated with two females, which were sacrificed on gestation day 17, and their litters were examined for adverse effects. Mating and fertility indices were not significantly altered by treatment. Male exposure to [Cr(pic)(3)] also had no effect on prenatal mortality, fetal weight, or gross or skeletal morphology. These results suggest that paternal dietary exposure to chromium(III) picolinate has little potential for adverse reproductive effects, even at exposure levels considerably higher than expected human exposures from nutritional supplements (1 mg of Cr per day or less).
吡啶甲酸铬（[Cr(pic)(3)]）是一种常用于人类的营养补充剂，也已被批准用于动物。人们对[Cr(pic)(3)]的使用产生了健康方面的担忧。在高剂量[Cr(pic)(3)]的情况下，对雌性小鼠的发育毒性测试表明，暴露胎儿的颈椎弓裂发生率更高，但这种情况并非始终具有重现性。在当前的研究中，使用雄性 CD-1 小鼠进一步评估其潜在的生殖或发育毒性。在交配前四周，雄性小鼠喂食提供 200mg/kg/天[Cr(pic)(3)]的饮食，与未处理的对照组进行比较。雌性小鼠不接受处理。每只雄性与两只雌性交配，在妊娠第 17 天处死雌性，并检查其幼仔是否有不良反应。处理对交配和生育指数没有显著影响。雄性暴露于[Cr(pic)(3)]也不会影响产前死亡率、胎儿体重或大体或骨骼形态。这些结果表明，即使在暴露水平远高于营养补充剂（每天 1 毫克铬或更少）预计的人类暴露水平，父亲的饮食暴露于吡啶甲酸铬也不太可能产生不良的生殖影响。
