Awodele O, Kale O E, Odewabi A O, Ekor M, Salau B A, Adefule-Ositelu A O
Department of Pharmacology, Therapeutics, and Toxicology, College of Medicine, University of Lagos, Nigeria.
Department of Pharmacology, Benjamin Carson (Snr.) School of Medicine, Babcock University, Nigeria.
J Tradit Complement Med. 2017 Jun 20;8(1):212-219. doi: 10.1016/j.jtcme.2017.06.002. eCollection 2018 Jan.
The global increase in acceptance and use of herbal remedies in recent times is still accompanied with poor knowledge of their potential adverse effects and the toxicological implications of their use are underestimated.
Bon-santé Cleanser (BSC), a polyherbal containing , , , is an "energizer and hormone booster". We assessed the effect of BSC on reproductive function after administration for 60 days in male Wistar rats. Rats (150-300 g) were assigned into four groups of 8/group. Control received distilled water (10 ml/kg) while other groups received BSC 250, 500 and 1000 mg/kg/day .. respectively. Animals were euthanized by cervical dislocation and samples collected for analysis.
BSC (250 mg/kg) elevated (p < 0.05) follicle stimulating hormone and luteinizing hormone levels respectively. BSC decreased sperm motility and the live-dead ratio at 1000 mg/kg and reduced reproductive hormone at 500 mg/kg and 1000 mg/kg respectively. BSC at 500 mg/kg increased (p < 0.05, = 3.18-13.21) testicular reduced glutathione level (50.3%) and catalase (43.7%) but not activities of superoxide dismutase, glutathione S-transferase, and malondialdehyde level. Further, BSC influenced Mg, Zn, Cu, P, Mn, Ni and Fe levels (p < 0.05). BSC (1000 mg/kg) decreased testis weight (p < 0.05) and induced mild inflammation characterized by atrophic tubules.
Overall, our data suggest BSC at low doses may increase reproductive hormones regulated by FSH and LH as observed in this study. However, BSC administration should be done with caution as it may induce reproductive toxicity in large doses.
近年来，全球范围内草药疗法的接受度和使用率不断上升，但人们对其潜在不良反应的了解仍然不足，对其使用的毒理学影响也被低估。
Bon-santé洁面乳（BSC）是一种含有多种草药的产品，包括[此处原文缺失草药名称]，号称“活力增强剂和激素促进剂”。我们评估了在雄性Wistar大鼠中连续60天给予BSC后对其生殖功能的影响。将大鼠（150 - 300克）分为四组，每组8只。对照组给予蒸馏水（10毫升/千克），而其他组分别给予250、500和1000毫克/千克/天的BSC。通过颈椎脱臼法对动物实施安乐死，并收集样本进行分析。
BSC（250毫克/千克）分别提高了（p < 0.05）促卵泡生成素和促黄体生成素水平。BSC在1000毫克/千克时降低了精子活力和活死比率，在500毫克/千克和1000毫克/千克时分别降低了生殖激素水平。500毫克/千克的BSC增加了（p < 0.05，[此处原文缺失相关数值] = 3.18 - 13.21）睾丸还原型谷胱甘肽水平（50.3%）和过氧化氢酶水平（43.7%），但超氧化物歧化酶、谷胱甘肽S - 转移酶的活性以及丙二醛水平未受影响。此外，BSC影响了镁、锌、铜、磷、锰、镍和铁的水平（p < 0.05）。BSC（1000毫克/千克）降低了睾丸重量（p < 0.05），并导致以肾小管萎缩为特征的轻度炎症。
总体而言，我们的数据表明，如本研究中所观察到的，低剂量的BSC可能会增加由促卵泡生成素和促黄体生成素调节的生殖激素水平。然而，使用BSC时应谨慎行事，因为大剂量使用可能会导致生殖毒性。
