Department of Emergency, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
J Zhejiang Univ Sci B. 2011 Mar;12(3):189-92. doi: 10.1631/jzus.B1000265.
To report clinical features and treatment of 16 cases of acute 2,4-dinitrophenol poisoning.
A total of 16 patients suffering from acute poisoning due to non-oral exposure to 2,4-dinitrophenol were sent to our hospital. Two died within 3 h after admission, while the other 14 responded to supportive treatment and hemoperfusion. Clinical features and treatment of the patients were retrospectively analyzed and presented.
Fourteen patients recovered and were discharged after four to six weeks of treatment. No obvious poisoning sequelae were found in the three-month follow-up.
Non-oral exposure to 2,4-dinitrophenol is toxic. Hemoperfusion and glucocorticoid treatments may be efficient measures to prevent mortality, but this requires further study.
报告 16 例急性 2,4-二硝基苯酚中毒患者的临床特征和治疗方法。
共收治 16 例因非口服接触 2,4-二硝基苯酚而中毒的患者。2 例患者在入院后 3 小时内死亡，其余 14 例患者接受了支持性治疗和血液灌流治疗。回顾性分析并报道了患者的临床特征和治疗情况。
14 例患者经 4 至 6 周治疗后康复出院。在三个月的随访中未发现明显的中毒后遗症。
非口服接触 2,4-二硝基苯酚具有毒性。血液灌流和糖皮质激素治疗可能是预防死亡的有效措施，但这需要进一步研究。
