Collier A, Wilson R, Bradley H, Thomson J A, Small M
Diabetic Clinic, Gartnavel General Hospital, Glasgow, UK.
Diabet Med. 1990 Jan;7(1):27-30. doi: 10.1111/j.1464-5491.1990.tb01302.x.
Free radical activity has been implicated in the development of diabetic vascular complications in Type 1 diabetes. The aim of the present study was to investigate the levels of free radical scavengers, particularly erythrocyte superoxide dismutase, plasma and erythrocyte lysate thiol, and caeruloplasmin in 22 Type 2 diabetic patients clinically free of complications, and 15 comparable non-diabetic control subjects. The concentration (median (range] of both superoxide dismutase (23 (10-39) vs 45 (25-75) mumol l-1; p less than 0.001) and plasma thiol (374 (172-523) vs 460 (386-595) mumol l-1; p less than 0.01) were reduced in the diabetic group. There were no significant differences in the concentration of erythrocyte lysate thiol (199 (114-520) vs 188 (114-328) mumol l-1) or plasma caeruloplasmin (18 (9-31) vs 24 (6-50) mumol l-1) between the groups. This reduction in superoxide dismutase and the imbalance in the redox status of the plasma and lysate thiol demonstrated is consistent with an increase in free radical activity in Type 2 diabetes.
自由基活性与1型糖尿病患者糖尿病血管并发症的发生有关。本研究旨在调查22例临床无并发症的2型糖尿病患者以及15例匹配的非糖尿病对照者体内自由基清除剂的水平，特别是红细胞超氧化物歧化酶、血浆和红细胞裂解液中的巯基以及铜蓝蛋白。糖尿病组中超氧化物歧化酶的浓度（中位数[范围]为23（10 - 39）对45（25 - 75）μmol l-1；p<0.001）和血浆巯基浓度（374（172 - 523）对460（386 - 595）μmol l-1；p<0.01）均降低。两组间红细胞裂解液巯基浓度（199（114 - 520）对188（114 - 328）μmol l-1）或血浆铜蓝蛋白浓度（18（9 - 31）对24（6 - 50）μmol l-1）无显著差异。超氧化物歧化酶的这种降低以及所显示的血浆和裂解液巯基氧化还原状态的失衡与2型糖尿病中自由基活性增加是一致的。
