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2009 年加拿大流感大流行规划和应对情况。

Influenza pandemic planning and performance in Canada, 2009.

机构信息

Rollins School of Public Health, Emory University, Atlanta, GA, USA.

出版信息

Can J Public Health. 2010 Nov-Dec;101(6):447-53. doi: 10.1007/BF03403962.

DOI:10.1007/BF03403962
PMID:21370779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6973708/
Abstract

This commentary evaluates Canadian actions following identification of pH1N1 influenza virus in 2009. We also report on some international issues affecting vaccine manufacture, and compare pH1N1 influenza vaccination programs in several industrialized countries. WHO's pandemic declaration was the trigger for Canada to take the following steps: (1) implement its sole source pandemic vaccine supply contract, (2) use an alternate, internationally-developed approach to authorize emergency use of adjuvant-containing vaccine not yet fully approved in Canada, (3) release stocks of antiviral, and (4) develop many health-related policies, through committees other than those normally used outside a pandemic. We note key successes and challenges in these steps, and suggest responses to two priority issues: first, improve planning for surges in demand for the clinical services that represent the main way in which severe disease impact was reduced, and second, establish from the outset of Public Health planning that immunization programs will phase use of vaccine in different target groups, as done elsewhere, reflecting realistic vaccine delivery rates and the likely early occurrence of the main epidemic wave.

摘要

本评论评价了加拿大在 2009 年发现 pH1N1 流感病毒后的行动。我们还报告了一些影响疫苗生产的国际问题,并比较了几个工业化国家的 pH1N1 流感疫苗接种计划。世界卫生组织的大流行宣布是加拿大采取以下步骤的触发因素:(1)实施其唯一的大流行疫苗供应合同,(2)使用另一种国际开发的方法,授权在加拿大尚未完全批准的含佐剂疫苗紧急使用,(3)释放抗病毒药物库存,以及(4)通过大流行期间通常不使用的委员会制定许多与健康相关的政策。我们注意到这些步骤中的关键成功和挑战,并对两个优先问题提出了应对建议:首先,改善对代表减轻严重疾病影响的主要途径的临床服务需求激增的规划,其次,从公共卫生规划的一开始就确定免疫接种计划将分阶段在不同目标群体中使用疫苗,就像其他地方一样,反映出实际的疫苗交付率和主要流行波的早期发生。

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BMJ. 2010 Jun 3;340:c2912. doi: 10.1136/bmj.c2912.
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Interim results: state-specific influenza A (H1N1) 2009 monovalent vaccination coverage - United States, October 2009-January 2010.临时结果:特定州的甲型 H1N1 流感 2009 年单价疫苗接种覆盖率 - 美国,2009 年 10 月至 2010 年 1 月。
MMWR Morb Mortal Wkly Rep. 2010 Apr 2;59(12):363-8.
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Seroprevalence Following the Second Wave of Pandemic 2009 H1N1 Influenza.2009年甲型H1N1流感大流行第二波后的血清流行率
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Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection.2009 年甲型 H1N1 流感病毒感染患者重症疾病的相关因素。
CMAJ. 2010 Feb 23;182(3):257-64. doi: 10.1503/cmaj.091884. Epub 2010 Jan 21.
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Lessons from a pandemic.大流行带来的启示。
Nature. 2010 Jan 14;463(7278):135-6. doi: 10.1038/463135b.
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Risk factors and outcomes among children admitted to hospital with pandemic H1N1 influenza.儿童因大流行 H1N1 流感住院的风险因素和结局。
CMAJ. 2010 Jan 12;182(1):39-44. doi: 10.1503/cmaj.091724. Epub 2009 Nov 19.
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