Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing, China.
Clin Toxicol (Phila). 2011 Feb;49(2):121-3. doi: 10.3109/15563650.2011.556643.
Cyanide is considered one of the most lethal poisons, reports on visual changes after acute cyanide poisoning are rare due to a low rate of survival of those having committed suicides.
A 30-year-old man developed visual loss in both eyes after inhaling sodium cyanide gas, but nothing abnormal was found in slit lamp microscope and indirect ophthalmoscope examinations 5 months later. In pattern visual evoked potential, the amplitude of P100 wave was apparently decreased. Humphrey perimetry examination and AccuMap multifocal visual evoked potentials objective perimetry showed severe defects of the central visual field. Magnetic resonance imaging revealed abnormal signal changes in bilateral putamen. Results of other examinations, including Farnsworth dichotomous color vision test, optical coherence tomography, retinal nerve fiber layer examination and flash electroretinography, were normal.
Although magnetic resonance imaging showed no changes in the signal of the visual pathway, clinical features and our test results suggest a possible lesion in the posterior visual pathway.
氰化物被认为是最致命的毒物之一，由于自杀者的存活率较低，鲜有关于急性氰化物中毒后视觉变化的报告。
一名 30 岁男子吸入氰化钠气体后双眼视力丧失，但 5 个月后裂隙灯显微镜和间接检眼镜检查均未见异常。在图形视觉诱发电位中，P100 波的振幅明显降低。Humphrey 视野检查和 AccuMap 多焦视觉诱发电位客观视野检查显示中心视野严重缺损。磁共振成像显示双侧壳核异常信号改变。包括 Farnsworth 二分色觉测试、光学相干断层扫描、视网膜神经纤维层检查和闪光视网膜电图在内的其他检查结果均正常。
尽管磁共振成像显示视觉通路信号无变化，但临床特征和我们的测试结果提示后视觉通路可能存在病变。
