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在印度和南非开始接受抗逆转录病毒治疗的患者中，与 HIV 相关的眼部疾病的谱不同。

Differing spectrum of HIV-associated ophthalmic disease among patients starting antiretroviral therapy in India and South Africa.

机构信息

Department of Clinical Research, London School of Hygiene and Tropical Medicine, UK.

出版信息

Trop Med Int Health. 2011 Mar;16(3):356-9. doi: 10.1111/j.1365-3156.2010.02712.x. Epub 2011 Jan 5.

DOI:10.1111/j.1365-3156.2010.02712.x
PMID:21371217
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3128924/
Abstract

Differences in the prevalence and spectrum of HIV-associated ophthalmic disease in Africa and Asia are not well documented. We studied two comparable cohorts of patients initiating antiretroviral therapy in Mumbai, India, and Cape Town, South Africa. The prevalence of HIV-associated ophthalmic disease was higher in the Indian population (17.5%) than in the South African population (12.1%). This was largely because of vitreo-retinal opportunistic infections (11.4%vs. 2.6%, respectively), notably cytomegalovirus retinitis. This difference persisted after adjusting for confounding factors (adjusted odds ratio=11.32, 95% confidence interval: 2.67-48.13), confirming a marked geographical difference in the prevalence of HIV-associated retinal disease.

摘要

在非洲和亚洲，与艾滋病毒相关的眼科疾病的流行率和范围的差异没有得到很好的记录。我们研究了在印度孟买和南非开普敦开始接受抗逆转录病毒治疗的两个可比队列的患者。与南非人群（12.1%）相比，印度人群中与艾滋病毒相关的眼科疾病的患病率更高（17.5%）。这主要是由于玻璃体液视网膜机会性感染（分别为 11.4%和 2.6%），特别是巨细胞病毒视网膜炎。在调整混杂因素后，这种差异仍然存在（调整后的优势比=11.32，95%置信区间：2.67-48.13），证实了与艾滋病毒相关的视网膜疾病的流行率在地理上存在明显差异。