Kothari Atul, Ramachandran V G, Gupta Piyush, Singh Bharat, Talwar Vibha
Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi 110 095, India.
J Health Popul Nutr. 2002 Dec;20(4):348-51.
Cytomegalovirus (CMV) is known to be a significant cause of morbidity and mortality following blood transfusion in children and immunocompromised adults. In India, it is not mandatory to screen donated blood for CMV in blood banks. Very few studies have been conducted in India to estimate the seroprevalence of this infection in voluntary blood donors. This study was conducted to estimate the seroprevalence of CMV among voluntary blood donors in Delhi, India. In this study, none of 200 donors tested positive for CMV IgM antibody, but 95% were positive for CMV IgG antibody. There was no statistically significant difference in seropositivity of CMV based on distribution of age. Of the 200 donors, 3% tested positive for HBsAg, 1% for HIV, 2% for hepatitis C virus, and 4.5% for syphilis. Since about 95% of blood donors in India are seropositive for CMV, it would seem superfluous to screen blood donors for CMV, as very few seronegative blood units would be available for transfusion. Other preventive strategies, such as leukoreduction, etc., could be more appropriate and cost-effective for the prevention of transmission of CMV through infected blood to immunosuppressed individuals.
巨细胞病毒（CMV）是儿童和免疫功能低下成人输血后发病和死亡的重要原因。在印度，血库中并非强制要求对捐献的血液进行巨细胞病毒筛查。在印度，很少有研究对自愿献血者中这种感染的血清阳性率进行评估。本研究旨在评估印度德里自愿献血者中巨细胞病毒的血清阳性率。在本研究中，200名献血者中无人CMV IgM抗体检测呈阳性，但95%的人CMV IgG抗体呈阳性。基于年龄分布，巨细胞病毒血清阳性率无统计学显著差异。在200名献血者中，3%的人乙肝表面抗原检测呈阳性，1%的人艾滋病毒检测呈阳性，2%的人丙型肝炎病毒检测呈阳性，4.5%的人梅毒检测呈阳性。由于印度约95%的献血者巨细胞病毒血清呈阳性，对献血者进行巨细胞病毒筛查似乎多余，因为可供输血的血清阴性血液单位很少。其他预防策略，如白细胞滤除等，可能对预防巨细胞病毒通过受感染血液传播给免疫抑制个体更为合适且具有成本效益。
