Department of Internal Medicine, University of Michigan,nn Arbor, MI 48109-5680, USA.
Arthritis Res Ther. 2011 Feb 28;13(1):203. doi: 10.1186/ar3264.
Patients with systemic lupus erythematosus have up to a 50-fold increased risk of developing atherosclerotic cardiovascular disease. Recent advances in the etiology of vascular damage in this disease stress the interplay of lupus-specific inflammatory factors with traditional cardiac risk factors, leading to increased endothelial damage. This review analyzes the putative role that immune dysregulation and lupus-specific factors may play in the pathogenesis of premature vascular damage in this disease. The potential role of various cytokines, in particular type I interferons, in the development of accelerated atherosclerosis is examined. Potential therapeutic targets are discussed.
系统性红斑狼疮患者发生动脉粥样硬化性心血管疾病的风险增加了多达 50 倍。该疾病血管损伤病因学的最新进展强调了狼疮特异性炎症因子与传统心脏危险因素的相互作用，导致内皮损伤增加。本综述分析了免疫失调和狼疮特异性因素在该疾病中导致血管早期损伤的发病机制中的可能作用。检查了各种细胞因子，特别是 I 型干扰素，在加速动脉粥样硬化发展中的潜在作用。讨论了潜在的治疗靶点。
