子痫前期与巨大儿出生风险。
Preeclampsia and the risk of large-for-gestational-age infants.
机构信息
Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
出版信息
Am J Obstet Gynecol. 2011 May;204(5):425.e1-6. doi: 10.1016/j.ajog.2010.12.030. Epub 2011 Mar 3.
OBJECTIVE
We sought to compare the risk of giving birth to large-for-gestational-age (LGA) infants in women with and without preeclampsia, after adjustment for obesity and glucose intolerance.
STUDY DESIGN
We conducted secondary analysis of a prospective database of pregnant women with and without preeclampsia who delivered infants from 1998 through 2006 at Massachusetts General Hospital (n = 17,465).
RESULTS
The risk of LGA was similar in women with and without preeclampsia (odds ratio, 0.81; 95% confidence interval, 0.59-1.14). After adjustment for body mass index, glucose intolerance, and other factors, the risk of LGA was significantly lower in women with preeclampsia compared to those without preeclampsia (odds ratio, 0.69; 95% confidence interval, 0.49-0.96). Stratified analysis in groups with a higher risk of LGA revealed that preeclampsia has a similar effect on the risk of LGA regardless of maternal obesity, glucose intolerance, parity, and race.
CONCLUSION
Preeclampsia appears to be characterized by reduced, and not increased, fetal growth.
目的
在调整肥胖和葡萄糖不耐受因素后，比较子痫前期患者与无子痫前期患者所分娩的巨大儿（LGA）的风险。
研究设计
我们对马萨诸塞州综合医院 1998 年至 2006 年期间分娩的子痫前期和无子痫前期孕妇前瞻性数据库进行了二次分析（n = 17465）。
结果
子痫前期患者与无子痫前期患者的 LGA 风险相似（比值比，0.81；95%置信区间，0.59-1.14）。调整体重指数、葡萄糖不耐受和其他因素后，子痫前期患者的 LGA 风险明显低于无子痫前期患者（比值比，0.69；95%置信区间，0.49-0.96）。在 LGA 风险较高的分组中进行的分层分析表明，子痫前期对 LGA 的风险的影响相似，无论母体肥胖、葡萄糖不耐受、产次和种族如何。
结论
子痫前期的特点似乎是胎儿生长减少，而不是增加。
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