Elias A N, Vaziri N D, Domurat E S, Pandian M R, Ansari M A, Yazdani M
Department of Medicine, University of California, Irvine.
J Pharmacol Exp Ther. 1990 Jan;252(1):438-41.
The concentrations of atrial natriuretic peptide, arginine vasopressin, aldosterone and the plasma renin activity were studied in male rats with carbon tetrachloride-induced compensated cirrhosis, and the results were compared to those of normal control animals. The rats with cirrhosis exhibited significantly higher plasma renin activity values when compared with the control group. However, plasma concentrations of atrial natriuretic peptide and arginine vasopressin were not significantly different in the two groups. Plasma aldosterone concentrations were significantly higher than those found in the normal control group in approximately 50% of the cirrhotic animals, and were equal to or less than the control values in the rest. This dissociation between plasma renin activity and aldosterone values in some of the cirrhotic animals is interesting and parallels observations made in humans with alcoholic cirrhosis. The results suggest that experimentally induced, apparently compensated cirrhosis may be associated with a perceived decrease in effective circulating volume, and that there is no absolute deficiency of atrial natriuretic peptide in this model of cirrhosis.
对四氯化碳诱导的代偿性肝硬化雄性大鼠的心房利钠肽、精氨酸加压素、醛固酮及血浆肾素活性浓度进行了研究，并将结果与正常对照动物的结果进行比较。与对照组相比，肝硬化大鼠的血浆肾素活性值显著更高。然而，两组间心房利钠肽和精氨酸加压素的血浆浓度无显著差异。约50%的肝硬化动物的血浆醛固酮浓度显著高于正常对照组，其余动物的血浆醛固酮浓度等于或低于对照值。部分肝硬化动物血浆肾素活性与醛固酮值之间的这种分离很有意思，与酒精性肝硬化患者的观察结果相似。结果表明，实验诱导的、明显代偿性肝硬化可能与有效循环血容量的感知减少有关，且在该肝硬化模型中不存在心房利钠肽的绝对缺乏。
