Centre of Expertise for Health and Work Ability, Finnish Institute of Occupational Health, Helsinki, Finland.
Cytokine. 2011 May;54(2):149-53. doi: 10.1016/j.cyto.2011.02.003. Epub 2011 Mar 2.
Previous studies suggest a role for IL-1β in the pathophysiology of upper extremity soft tissue disorders (UESTDs). We studied the levels of interleukin-1 family members in patients with incipient UESTDs and compared them with healthy controls. In this case control study, we included 163 patients with UESTDs and symptom duration shorter than 1 month and 42 healthy controls matched for age and gender at the group level. Serum levels of cytokines IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-18, IL-33, TNFα and sensitized C-reactive protein as well as IL-1 family soluble receptors sIL-1RII and sST2 were assessed. We used unconditional logistic regression models to study the associations between cytokines and UESTDs. After adjustment for potential confounders, the serum levels of sIL-1RII (p<0.001) and sST2 (p=0.014) were higher in the patients than the controls. The level of IL-18 was lower in the patients than the controls (p=0.005). There were no significant differences between the patients and controls regarding the levels of IL-1α, IL-1β, IL-1Ra, IL-33, IL-6, IL-8, TNFα, or sensitized C-reactive protein. The levels of circulating sIL-1RII and IL-18 are associated with incipient UESTDs, suggesting an important role for these IL-1 family members in the early course of UESTDs.
先前的研究表明白细胞介素-1β（IL-1β）在上肢软组织疾病（UESTD）的病理生理学中起作用。我们研究了初发 UESTD 患者白细胞介素家族成员的水平，并将其与健康对照进行了比较。在这项病例对照研究中，我们纳入了 163 例 UESTD 患者，其症状持续时间短于 1 个月，以及 42 名年龄和性别与组水平相匹配的健康对照者。评估了细胞因子白细胞介素-1α（IL-1α）、白细胞介素-1β（IL-1β）、白细胞介素-1 受体拮抗剂（IL-1Ra）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、白细胞介素-18（IL-18）、白细胞介素-33（IL-33）、肿瘤坏死因子-α（TNFα）和敏感 C 反应蛋白以及白细胞介素-1 家族可溶性受体 sIL-1RII 和 sST2 的血清水平。我们使用无条件逻辑回归模型研究细胞因子与 UESTD 之间的关系。在调整潜在混杂因素后，患者的血清 sIL-1RII（p<0.001）和 sST2（p=0.014）水平高于对照组。患者的 IL-18 水平低于对照组（p=0.005）。患者和对照组之间在白细胞介素-1α、白细胞介素-1β、白细胞介素-1 受体拮抗剂、白细胞介素-33、白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α或敏感 C 反应蛋白的水平方面没有显著差异。循环 sIL-1RII 和 IL-18 的水平与初发 UESTD 相关，表明这些白细胞介素家族成员在 UESTD 的早期发病过程中起重要作用。
