Halabe A, Wong N L, Wong E F, Sutton R A
Department of Medicine, University of British Columbia, Vancouver, Canada.
Metabolism. 1990 Feb;39(2):209-12. doi: 10.1016/0026-0495(90)90077-p.
Ionized calcium is a stimulator for the release of several peptide hormones. Atrial natriuretic factor (ANF) is a peptide hormone released from atrial tissue in response to atrial distension or volume expansion. In the present study, we have examined the effect of an oral calcium load in healthy controls and renal stone patients with idiopathic hypercalciuria. Our results demonstrated that ANF release increased in both groups in response to a calcium load. However, idiopathic hypercalciuric patients presented lower basal ANF levels in the presence of high calcitriol levels. The role of calcitriol on ANF release remains to be evaluated.
离子钙是几种肽类激素释放的刺激物。心钠素（ANF）是一种肽类激素，由心房组织在心房扩张或容量增加时释放。在本研究中，我们检测了口服钙负荷对健康对照者和特发性高钙尿症肾结石患者的影响。我们的结果表明，两组在钙负荷后ANF释放均增加。然而，在高骨化三醇水平存在的情况下，特发性高钙尿症患者的基础ANF水平较低。骨化三醇对ANF释放的作用仍有待评估。
