de Swart P M, Sokole E B, Wilmink J M
Department of Medicine (Division of Nephrology), Academic Medical Center, Amsterdam, The Netherlands.
J Urol. 1998 Mar;159(3):669-72. doi: 10.1097/00005392-199803000-00009.
A decreased concentration of magnesium in the urine is a risk factor for renal calcium stone disease that may be caused by decreased enteral absorption of magnesium. We analyze the possible reciprocal influences of enteral absorption of calcium and magnesium in patients with renal stone disease.
We measured the fractional enteral absorption of 47calcium and 28magnesium in 11 patients with renal calcium stone disease, including 8 with and 3 without hypercalciuria. Two tests were performed using calcium and magnesium, respectively, followed by another test in which the enteral absorption of calcium and magnesium was measured after both cations were administered together.
We noted no clear influence of either cation on the absorption of the other in the 3 patients without hypercalciuria. However, in the 8 hypercalciuric patients enteral calcium absorption decreased after the concurrent administration of magnesium and enteral magnesium absorption increased after the concurrent administration of calcium. Each effect was proportional to the other.
The results of this study indicate that the oral supplementation of magnesium in patients with hyperabsorptive hypercalciuria and renal calcium stone disease is favorable because it decreases calcium absorption and increases magnesium absorption. Both factors may reduce risk factors for renal calcium stone formation.
尿镁浓度降低是肾钙结石病的一个危险因素，可能由肠道镁吸收减少引起。我们分析了肾结石病患者肠道钙和镁吸收之间可能的相互影响。
我们测量了11例肾钙结石病患者（包括8例高钙尿症患者和3例非高钙尿症患者）的钙和镁的肠道吸收分数。分别使用钙和镁进行了两项测试，然后进行另一项测试，即在同时给予两种阳离子后测量钙和镁的肠道吸收情况。
我们注意到，在3例非高钙尿症患者中，两种阳离子中的任何一种对另一种的吸收均无明显影响。然而，在8例高钙尿症患者中，同时给予镁后肠道钙吸收减少，同时给予钙后肠道镁吸收增加。每种效应与另一种效应成正比。
本研究结果表明，对于高吸收性高钙尿症和肾钙结石病患者，口服补充镁是有益的，因为它可以减少钙吸收并增加镁吸收。这两个因素都可能降低肾钙结石形成的危险因素。
