人白细胞介素-1受体拮抗剂互补DNA的一级结构及功能表达
Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist.
作者信息
Eisenberg S P, Evans R J, Arend W P, Verderber E, Brewer M T, Hannum C H, Thompson R C
机构信息
Synergen Inc., Boulder, Colorado 80301.
出版信息
Nature. 1990 Jan 25;343(6256):341-6. doi: 10.1038/343341a0.
Human monocytes induced with adherent IgG secrete an interleukin-1 receptor antagonist which could be important for the in vivo regulation of IL-1 activity. A complementary DNA for this molecule has been isolated from a human monocyte library. Analysis of monocyte RNA indicates that the gene is transcriptionally regulated. The sequence of the receptor antagonist indicates that it is structurally similar to IL-1 beta. Expression of the cDNA in Escherichia coli yields IL-1 receptor antagonist activity.
用黏附的免疫球蛋白诱导的人单核细胞分泌一种白细胞介素-1受体拮抗剂，这可能对白细胞介素-1活性的体内调节很重要。已从人单核细胞文库中分离出该分子的互补DNA。对单核细胞RNA的分析表明该基因受到转录调控。受体拮抗剂的序列表明它在结构上与白细胞介素-1β相似。该互补DNA在大肠杆菌中的表达产生白细胞介素-1受体拮抗剂活性。
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