哺乳动物剪接体组装所需的因子定位于细胞核中的离散区域。
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus.
作者信息
Fu X D, Maniatis T
机构信息
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
出版信息
Nature. 1990 Feb 1;343(6257):437-41. doi: 10.1038/343437a0.
DOI:10.1038/343437a0
PMID:2137203
Abstract
A monoclonal antibody raised against mammalian spliceosomes specifically recognizes a non-snRNP factor required for spliceosome assembly. This splicing factor is highly concentrated in discrete regions within the nucleus, in a pattern that is a distinct subset of that seen with anti-snRNP antibodies. These observations are evidence that spliceosome assembly could be compartmentalized within the nucleus.
摘要
一种针对哺乳动物剪接体产生的单克隆抗体特异性识别剪接体组装所需的一种非小核核糖核蛋白（snRNP）因子。这种剪接因子高度集中在细胞核内的离散区域，其分布模式是抗snRNP抗体所显示模式的一个独特子集。这些观察结果证明剪接体组装可能在细胞核内进行区域化。
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