Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, The Netherlands.
Hum Reprod. 2011 May;26(5):1112-8. doi: 10.1093/humrep/der051. Epub 2011 Mar 3.
This study examined the relationship between emotional distress as measured by the Hospital Anxiety and Depression Scale (HADS) and the Fertility Quality of Life (FertiQoL) questionnaire.
The FertiQoL and HADS were distributed to a random sample of 785 patients attending 29 Dutch clinics for medically assisted reproduction. FertiQoL was psychometrically tested for reliability. Pearson's correlations were calculated between subscales of FertiQoL and HADS. Using an independent t-test, differences between patient subgroups were computed for both instruments. The threshold for clinically meaningful depression/anxiety on the HADS subscales was used to ascertain the critical threshold for high distress on the FertiQoL scales.
FertiQoL and HADS were completed by 583 patients (response 74%). Reliability of FertiQoL scales was high (reliability coefficient between 0.72 and 0.91). Significant negative correlations were found between FertiQoL subscales and HADS scores for anxiety and depression, ranging from -0.29 to -0.71. Means on FertiQoL scales and HADS scales of couples undergoing an assisted reproductive technology (ART) treatment and a non-ART treatment did not differ significantly. Patients scoring above the HADS threshold for pathology on anxiety had an average FertiQoL score of 58.8, whereas patients exceeding the HADS depression threshold had a FertiQoL total score of 51.9 (range 0-100).
Our study confirms the expected negative relation between quality of life as measured by FertiQoL and anxiety and depression. The data support that FertiQoL reliably measures QoL in women facing infertility. FertiQoL enables clinicians to tailor care more specifically to the patient in a comprehensive way.
本研究考察了医院焦虑抑郁量表（HADS）测量的情绪困扰与生育质量生活（FertiQoL）问卷之间的关系。
FertiQoL 和 HADS 分发给参加 29 家荷兰辅助生殖诊所的 785 名随机患者。对 FertiQoL 的信度进行了心理测试。计算了 FertiQoL 子量表和 HADS 之间的 Pearson 相关系数。使用独立 t 检验，计算了两个工具中患者亚组之间的差异。使用 HADS 子量表的临床有意义的抑郁/焦虑阈值来确定 FertiQoL 量表上高困扰的临界阈值。
583 名患者（应答率为 74%）完成了 FertiQoL 和 HADS。FertiQoL 量表的可靠性很高（可靠性系数在 0.72 到 0.91 之间）。FertiQoL 子量表与 HADS 焦虑和抑郁评分之间存在显著的负相关，范围从-0.29 到-0.71。接受辅助生殖技术（ART）治疗和非-ART 治疗的夫妇的 FertiQoL 量表和 HADS 量表的平均值没有显著差异。在焦虑方面 HADS 病理学评分超过阈值的患者的 FertiQoL 平均得分为 58.8，而 HADS 抑郁阈值超过的患者的 FertiQoL 总得分则为 51.9（范围 0-100）。
我们的研究证实了 FertiQoL 测量的生活质量与焦虑和抑郁之间的预期负相关。数据支持 FertiQoL 可靠地测量面临不孕的女性的生活质量。FertiQoL 使临床医生能够以全面的方式更具体地为患者提供护理。
