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抑制癌症恶病质。

InACTIVatINg cancer cachexia.

机构信息

Eccles Institute of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, UT 84112, USA.

出版信息

Dis Model Mech. 2011 May;4(3):283-5. doi: 10.1242/dmm.007658. Epub 2011 Mar 3.

DOI:10.1242/dmm.007658
PMID:21372048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3097449/
Abstract

Summary of and comment on a recent paper entitled ‘Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival’ (Zhou et al., 2010).

摘要

标题为“ActRIIB 拮抗作用逆转癌症恶病质和肌肉减少症导致生存期延长”的一篇近期论文的总结与述评（Zhou 等，2010 年）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/654b/3097449/ec5d74cb578e/DMM007658F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/654b/3097449/ec5d74cb578e/DMM007658F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/654b/3097449/ec5d74cb578e/DMM007658F1.jpg

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Cell. 2010 Aug 20;142(4):531-43. doi: 10.1016/j.cell.2010.07.011.
2
During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.在肌肉萎缩期间，粗肌丝成分（而非细肌丝成分）通过MuRF1依赖的泛素化作用而降解。
J Cell Biol. 2009 Jun 15;185(6):1083-95. doi: 10.1083/jcb.200901052. Epub 2009 Jun 8.
3
Mechanisms of cancer cachexia.癌症恶病质的机制。
癌症恶病质中肌肉消耗的数学模型
J Clin Med. 2020 Jun 28;9(7):2029. doi: 10.3390/jcm9072029.
4
Muscle alterations in the development and progression of cancer-induced muscle atrophy: a review.癌症相关肌肉萎缩发生发展过程中的肌肉改变：综述。
J Appl Physiol (1985). 2020 Jan 1;128(1):25-41. doi: 10.1152/japplphysiol.00622.2019. Epub 2019 Nov 14.
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The Mechanical Stimulation of Myotubes Counteracts the Effects of Tumor-Derived Factors Through the Modulation of the Activin/Follistatin Ratio.肌管的机械刺激通过调节激活素/卵泡抑素比值来抵消肿瘤衍生因子的作用。
Front Physiol. 2019 Apr 24;10:401. doi: 10.3389/fphys.2019.00401. eCollection 2019.
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