一条与癌症恶病质相关的转化生长因子-β信号通路。
A TGF-β pathway associated with cancer cachexia.
作者信息
Guttridge Denis C
机构信息
Department of Molecular Virology, Immunology and Medical Genetics, Arthur G. James Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, Ohio, USA.
出版信息
Nat Med. 2015 Nov;21(11):1248-9. doi: 10.1038/nm.3988.
Abstract
Cancer cachexia leads to involuntary weight loss resulting from the atrophy of skeletal muscle and adipose tissues. Now, in metastatic mouse models of cancer, investigators reveal a cross talk pathway between bone and muscle that provides a new understanding of wasting in advanced cancers.
摘要
癌症恶病质会导致骨骼肌和脂肪组织萎缩，进而引起非自愿性体重减轻。如今，在癌症转移小鼠模型中，研究人员揭示了骨骼与肌肉之间的一种相互作用途径，这为深入了解晚期癌症中的消瘦现象提供了新的视角。
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