Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Towada, Aomori 034–8628, Japan.
Biol Pharm Bull. 2011;34(3):307-10. doi: 10.1248/bpb.34.307.
Adipose tissue is now regarded as an active endocrine organ which can secrete various cytokines. Adipocyte-derived cytokines are termed adipocytokines (adipocytes+cytokine). Adipocytokines can affect vascular systems to prevent or exacerbate obesity-related vascular complications, including diabetes-related vascular dysfunction, hypertension, and atherosclerosis. However, their basic vascular functions remain to be fully determined. In this manuscript, I summarize our recent findings on the vascular effects of 5 newly identified adipocytokines (omentin, visfatin, nesfatin, vaspin, and chemerin), with a special focus on 1) vascular contractile reactivity, and 2) vascular inflammatory response/injury. These novel adipocytokines may be important future targets for the development of drugs and therapy for treating metabolic vascular disorders.
脂肪组织现在被认为是一种活跃的内分泌器官，能够分泌各种细胞因子。脂肪细胞衍生的细胞因子被称为脂肪细胞因子（脂肪细胞+细胞因子）。脂肪细胞因子可以影响血管系统，以预防或加剧与肥胖相关的血管并发症，包括与糖尿病相关的血管功能障碍、高血压和动脉粥样硬化。然而，它们的基本血管功能仍有待充分确定。在本文中，我总结了我们最近关于 5 种新鉴定的脂肪细胞因子（网膜素、内脏脂肪素、nesfatin、vaspin 和 chemerin）对血管作用的发现，特别关注 1）血管收缩反应性，和 2）血管炎症反应/损伤。这些新型脂肪细胞因子可能是未来开发治疗代谢性血管疾病药物和疗法的重要目标。
