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带有环氧乙烷环的生物活性甾体

Bioactive Steroids Bearing Oxirane Ring.

作者信息

Dembitsky Valery M

机构信息

Centre for Applied Research, Innovation and Entrepreneurship, Lethbridge College, 3000 College Drive South, Lethbridge, AB T1K 1L6, Canada.

出版信息

Biomedicines. 2023 Aug 9;11(8):2237. doi: 10.3390/biomedicines11082237.

DOI:10.3390/biomedicines11082237
PMID:37626733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10452232/
Abstract

This review explores the biological activity and structural diversity of steroids and related isoprenoid lipids, with a particular focus on compounds containing an oxirane ring. These natural compounds are derived from fungi, fungal endophytes, as well as extracts of plants, algae, and marine invertebrates. To evaluate their biological activity, an extensive examination of refereed literature sources was conducted, including in vivo and in vitro studies and the utilization of the QSAR method. Notable properties observed among these compounds include strong anti-inflammatory, antineoplastic, antiproliferative, anti-hypercholesterolemic, antiparkinsonian, diuretic, anti-eczematic, anti-psoriatic, and various other activities. Throughout this review, 3D graphs illustrating the activity of individual steroids are presented, accompanied by images of selected terrestrial or marine organisms. Furthermore, this review provides explanations for specific types of biological activity associated with these compounds. The data presented in this review are of scientific interest to the academic community and carry practical implications in the fields of pharmacology and medicine. By analyzing the biological activity and structural diversity of steroids and related isoprenoid lipids, this review offers valuable insights that contribute to both theoretical understanding and applied research. This review draws upon data from various authors to compile information on the biological activity of natural steroids containing an oxirane ring.

摘要

本综述探讨了甾体及其相关类异戊二烯脂质的生物活性和结构多样性，特别关注含有环氧乙烷环的化合物。这些天然化合物来源于真菌、真菌内生菌以及植物、藻类和海洋无脊椎动物的提取物。为了评估它们的生物活性，我们对参考文献来源进行了广泛的研究，包括体内和体外研究以及定量构效关系（QSAR）方法的应用。这些化合物中观察到的显著特性包括强大的抗炎、抗肿瘤、抗增殖、抗高胆固醇血症、抗帕金森病、利尿、抗湿疹、抗银屑病以及各种其他活性。在本综述中，展示了说明单个甾体活性的三维图，并配有选定的陆地或海洋生物的图像。此外，本综述还对与这些化合物相关的特定类型的生物活性进行了解释。本综述中呈现的数据对学术界具有科学价值，并在药理学和医学领域具有实际意义。通过分析甾体及其相关类异戊二烯脂质的生物活性和结构多样性，本综述提供了有价值的见解，有助于理论理解和应用研究。本综述借鉴了不同作者的数据，汇编了有关含有环氧乙烷环的天然甾体生物活性的信息。

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