Department of Nephrology, Lin-Kou Chang Gung Memorial Hospital, Taipei, Taiwan.
Blood Purif. 2011;32(2):89-95. doi: 10.1159/000324196. Epub 2011 Mar 2.
Hepatitis B virus (HBV) and hepatitis C virus (HCV) coinfection in comparison with single HBV infection causes more severe liver disease in nonuremic population. The long-term impact of HBV/HCV coinfection on severity of liver diseases and patient survival in hemodialysis patients is unclear. Forty-eight HBV-positive patients and 19 HBV/HCV-positive patients were followed up from February 1996 to September 2006. During 10-year follow-up, there was no difference in acute hepatitis episodes, abnormal serum alanine aminotransferase period, occurrence of cirrhosis and hepatocellular carcinoma, and patient survival between the two groups. The serum HBV DNA levels in HBV/HCV-positive patients were significantly lower than those in HBV-positive patients during the first 27-month follow-up. In conclusion, HCV infection suppresses the serum HBV DNA level in hemodialysis patients. Nevertheless, HBV/HCV coinfection in comparison with single HBV infection does not cause more severe liver diseases or reduce patient survival in hemodialysis patients during 10-year follow-up.
乙型肝炎病毒 (HBV) 和丙型肝炎病毒 (HCV) 合并感染与单纯 HBV 感染相比，在非尿毒症人群中可导致更严重的肝脏疾病。HBV/HCV 合并感染对血液透析患者肝脏疾病严重程度和患者生存的长期影响尚不清楚。1996 年 2 月至 2006 年 9 月期间，对 48 例 HBV 阳性患者和 19 例 HBV/HCV 阳性患者进行了随访。在 10 年的随访中，两组之间在急性肝炎发作、异常血清丙氨酸氨基转移酶期、肝硬化和肝细胞癌的发生以及患者生存率方面均无差异。在最初的 27 个月随访中，HBV/HCV 阳性患者的血清 HBV DNA 水平明显低于 HBV 阳性患者。总之，HCV 感染可抑制血液透析患者的血清 HBV DNA 水平。然而，在 10 年的随访中，与单纯 HBV 感染相比，HBV/HCV 合并感染并未导致血液透析患者发生更严重的肝脏疾病或降低患者生存率。
