Helfer E L, Miller J L, Rose L I
Endocrinology-Metabolism Department, Hahnemann University, Philadelphia, Pennsylvania.
Am J Med Sci. 1990 Feb;299(2):94-7. doi: 10.1097/00000441-199002000-00003.
Many physicians routinely measure the gonadotropins PRL, LH, and FSH and the androgens dehydroepiandrosterone (DHEA), androstenedione (ADIONE), and testosterone, as well as testosterone's biologically active fractions in the evaluation of hirsute women. Is this cost effective? To answer this question, 38 consecutive premenopausal hirsute women were evaluated. Two women each had minor elevations in PRL and FSH, and 11 had minor elevations in LH. Three women had minor elevations in the LH/FSH ratio, and only one was above a ratio of 3, believed to be indicative of polycystic ovarian syndrome. Because these gonadotropin elevations did not correlate with the androgens measured and were of no value in the diagnosis or management of these women, they were not believed to be cost effective. Their routine measurements should be abandoned.
许多医生在评估多毛症女性时，通常会常规检测促性腺激素泌乳素（PRL）、促黄体生成素（LH）和促卵泡生成素（FSH），以及雄激素脱氢表雄酮（DHEA）、雄烯二酮（ADIONE）和睾酮，还有睾酮的生物活性组分。这样做是否具有成本效益？为了回答这个问题，对38名连续的绝经前多毛症女性进行了评估。两名女性的PRL和FSH略有升高，11名女性的LH略有升高。三名女性的LH/FSH比值略有升高，只有一名女性的比值高于3，一般认为这表明患有多囊卵巢综合征。由于这些促性腺激素升高与所检测的雄激素无关，且对这些女性的诊断或治疗没有价值，因此不认为它们具有成本效益。应放弃常规检测。
