乳腺腺肌上皮瘤：一个复杂的诊断难题。
Adenomyoepithelioma of the Breast: An Intricate Diagnostic Problem.
作者信息
Catena Fausto, Santini Donatella, Di Saverio Salomone, Ansaloni Luca, Taffurelli Mario
机构信息
Anesthesiological and Surgical Sciences DPT, St Orsola-Malpighi University Hospital Bologna, Italy.
出版信息
Breast Care (Basel). 2008;3(2):125-127. doi: 10.1159/000119727. Epub 2008 Apr 15.
Abstract
BACKGROUND
Adenomyoepithelioma (AME) of the breast is a biphasic very uncommon tumour with epithelial/ my-oepithelial components. It can be easily recognised in an excised lesion, but it is more difficult to make a definitive diagnosis with needle biopsy. CASE REPORT: We report the case of a 42-year-old woman who presented with a mass in her right breast. The patient underwent a fine needle aspiration, and a diagnosis of C5 carcinoma was made. Neoadjuvant treatment was proposed to the patient but she refused and was referred to a third level centre where a needle core biopsy was performed and a diagnosis suggestive of AME was made. CONCLUSION: If there is cytological atypia, AME may be confused with infiltrating ductal carcinoma in needle biopsies because of limited tissue sampling.
摘要
背景
乳腺腺肌上皮瘤（AME）是一种具有上皮/肌上皮成分的双相性非常罕见的肿瘤。在切除的病变中很容易识别，但通过针吸活检做出明确诊断则较为困难。病例报告：我们报告一例42岁女性，其右乳出现肿块。患者接受了细针穿刺抽吸，诊断为C5癌。向患者提出新辅助治疗，但她拒绝了，并被转诊至三级中心，在那里进行了粗针穿刺活检，诊断提示为AME。结论：如果存在细胞学异型性，由于组织取样有限，AME在针吸活检中可能会与浸润性导管癌混淆。
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本文引用的文献
1
Pathologic quiz case: a rapidly increasing breast mass in a postmenopausal woman. Malignant adenomyoepithelioma.病理病例问答：一名绝经后女性乳房肿物迅速增大。恶性腺肌上皮瘤。
Arch Pathol Lab Med. 2004 Feb;128(2):235-6. doi: 10.5858/2004-128-235-PQCARI.
2
Malignant adenomyoepithelioma of the breast with malignant proliferation of epithelial and myoepithelial elements: a case report and review of the literature.乳腺恶性腺肌上皮瘤伴上皮及肌上皮成分恶性增殖：一例报告并文献复习
Arch Pathol Lab Med. 2000 Apr;124(4):632-6. doi: 10.5858/2000-124-0632-MAOTBW.
3
Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours?乳腺腺肌上皮瘤和唾液腺上皮-肌上皮癌是相同的肿瘤吗？
Virchows Arch. 1998 Sep;433(3):285-8. doi: 10.1007/s004280050249.
4
Carcinomas of the breast showing myoepithelial cell differentiation. A review of the literature.
Virchows Arch. 1998 Apr;432(4):303-10. doi: 10.1007/s004280050170.
5
The myothelia (myoepithelial cells). Normal state; regressive changes; hyperplasia; tumors.肌上皮（肌上皮细胞）。正常状态；退行性改变；增生；肿瘤。
Curr Top Pathol. 1970;53:161-220.
6
Adenomyoepithelioma of the breast.
Hum Pathol. 1987 Dec;18(12):1232-7. doi: 10.1016/s0046-8177(87)80406-9.
7
Myoepithelial lesions of the breast. Myoepitheliosis, adenomyoepithelioma, and myoepithelial carcinoma.乳腺肌上皮病变。肌上皮增生、腺肌上皮瘤和肌上皮癌。
Am J Surg Pathol. 1991 Jun;15(6):554-68. doi: 10.1097/00000478-199106000-00004.
8
Adenomyoepithelioma of the breast. A spectrum of biologic behavior.乳腺腺肌上皮瘤。生物学行为谱。
Am J Surg Pathol. 1992 Sep;16(9):868-76. doi: 10.1097/00000478-199209000-00005.
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