乳腺腺肌上皮瘤伴恶性转化及反复局部复发：1例报告
Adenomyoepithelioma of the breast with malignant transformation and repeated local recurrence: A case report.
作者信息
Oda Goshi, Nakagawa Tsuyoshi, Mori Mio, Fujioka Tomoyuki, Onishi Iichiro
机构信息
Department of Breast Surgery, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
Department of Radiology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan.
出版信息
World J Clin Cases. 2021 Oct 16;9(29):8864-8870. doi: 10.12998/wjcc.v9.i29.8864.
BACKGROUND
Adenomyoepithelioma (AME) of the breast is a rare type of benign breast tumor. Many AMEs show benign behavior, but reports of the malignant type are rare. We present the case of a patient with AME with repeated local recurrences and further malignant transformation.
CASE SUMMARY
A 53-year-old woman visited our hospital with a 16-mm palpable mass in the right breast. A core needle biopsy was performed. The pathological diagnosis was AME. Lumpectomy with a safety margin was performed without axillary lymph node dissection (ALND). Two years later, local recurrence developed, and the patient again underwent lumpectomy with a safety margin. The pathology showed malignant AME, and the margin was negative. Eight months later, local recurrence developed again in the same location, and a total mastectomy was performed without ALND. The pathological diagnosis was malignant AME. The patient was disease-free for three years posttreatment.
CONCLUSION
The treatment of AME requires caution, as it may exhibit repeated recurrences after local excision as well as malignant transformation.
背景
乳腺腺肌上皮瘤（AME）是一种罕见的乳腺良性肿瘤。许多AME表现为良性行为，但恶性类型的报道很少。我们报告一例AME患者，出现反复局部复发并进一步发生恶性转化。
病例摘要
一名53岁女性因右乳可触及一个16毫米的肿块前来我院就诊。进行了粗针活检。病理诊断为AME。在未进行腋窝淋巴结清扫（ALND）的情况下，进行了带安全切缘的肿块切除术。两年后，出现局部复发，患者再次接受了带安全切缘的肿块切除术。病理显示为恶性AME，切缘阴性。八个月后，同一部位再次出现局部复发，在未进行ALND的情况下进行了全乳房切除术。病理诊断为恶性AME。患者治疗后三年无疾病复发。
结论
AME的治疗需要谨慎，因为它在局部切除后可能会反复复发以及发生恶性转化。
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