School of Chemistry, University of Bristol, Cantocks Close, Bristol, BS8 1TS, UK.
Chem Soc Rev. 2011 Aug;40(8):4295-306. doi: 10.1039/c0cs00152j. Epub 2011 Mar 4.
In recent years our ability to design and assemble peptide-based materials and objects de novo (i.e. from first principles) has improved considerably. This brings us to a point where the resulting assemblies are quite sophisticated and amenable to engineering in new functions. Whilst such systems could be used in a variety of ways, biological applications are of particular interest because of the demand for biocompatible, readily produced systems with potential as drug-delivery agents, components of biosensors and scaffolds for 3D cell and tissue culture. This tutorial review describes the building blocks (or tectons) that are being used in peptide assembly, highlights a range of materials and objects that have been produced, notably hydrogels and virus-like particles, and introduces a number of potential applications for the designs.
近年来，我们设计和组装基于肽的材料和物体的能力有了显著提高（即从头开始）。这使得我们能够制造出非常复杂且易于赋予新功能的组装体。虽然这些系统可以有多种用途，但生物应用特别有趣，因为人们需要具有生物相容性、易于生产且具有作为药物输送剂、生物传感器组件和 3D 细胞和组织培养支架的潜力的系统。本教程综述描述了在肽组装中使用的构建块（或 tectons），重点介绍了已经生产的一系列材料和物体，特别是水凝胶和类病毒颗粒，并介绍了这些设计的一些潜在应用。
