• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

采用断端法研究环磷酸鸟苷（cGMP）对兔耳廓的作用。

The effect of cGMP in rabbit auricle as studied by a cut-end method.

作者信息

Tuganowski W, Kopeć P

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1978 Oct;304(3):211-3. doi: 10.1007/BF00507960.

DOI:10.1007/BF00507960
PMID:213737
Abstract

Cyclic GMP was applied to the rabbit right auricle by a cut-end method. The nucleotide decreased the spontaneous rate, hyperpolarized the cell membrane and reduced the amplitude and the slow component of the action potential. It also decreased the force of contraction. These results suggest that cGMP may be the mediator of the action of acetylcholine in the rabbit auricle.

摘要

采用断端法将环磷酸鸟苷（cGMP）应用于兔右心房。该核苷酸降低了自发频率，使细胞膜超极化，并降低了动作电位的幅度和慢成分。它还降低了收缩力。这些结果表明，cGMP可能是乙酰胆碱在兔心房中作用的介质。

相似文献

1
The effect of cGMP in rabbit auricle as studied by a cut-end method.采用断端法研究环磷酸鸟苷（cGMP）对兔耳廓的作用。
Naunyn Schmiedebergs Arch Pharmacol. 1978 Oct;304(3):211-3. doi: 10.1007/BF00507960.
2
The influence of dibutyryl cGMP on the rabbit auricle.
Pol J Pharmacol Pharm. 1978 Jan-Feb;30(1):73-5.
3
Inotropic effect of noradrenaline and acetylcholine in the rabbit auricle studied by a cut-end method.采用断端法研究去甲肾上腺素和乙酰胆碱对兔耳心的变力作用。
Pol J Pharmacol Pharm. 1977 Nov-Dec;29(6):657-61.
4
The effect of intracellular cyclic nucleotides and calcium on the action potential and acetylcholine response of isolated cardiac cells.细胞内环核苷酸和钙对离体心脏细胞动作电位及乙酰胆碱反应的影响。
Pflugers Arch. 1982 Feb;392(4):307-14. doi: 10.1007/BF00581624.
5
8-bromo-guanosine-3',5' -monophosphate mimics the effect of acetylcholine on slow response action potential and contractile force in mammalian atrial myocardium.
J Mol Cell Cardiol. 1978 Jun;10(6):573-86. doi: 10.1016/0022-2828(78)90015-9.
6
Effects of acetylcholine and cyclic nucleotides on the bullfrog atrial muscle.乙酰胆碱和环核苷酸对牛蛙心房肌的作用。
Recent Adv Stud Cardiac Struct Metab. 1976;11:57-61.
7
Does cyclic GMP mediate the negative inotropic effect of acetylcholine in the heart?
Nature. 1977 May 5;267(5606):72-4. doi: 10.1038/267072a0.
8
Adenosine inhibits the positive inotropic effect of 3-isobutyl-1-methylxanthine in papillary muscles without effect on cyclic AMP or cyclic GMP.腺苷可抑制3-异丁基-1-甲基黄嘌呤对乳头肌的正性肌力作用，而对环磷酸腺苷（cAMP）或环磷酸鸟苷（cGMP）无影响。
Br J Pharmacol. 1988 Apr;93(4):729-38. doi: 10.1111/j.1476-5381.1988.tb11456.x.
9
Effects of inhibitors of cGMP-dependent protein kinase in atrial heart and aortic smooth muscle from rats.环磷酸鸟苷依赖性蛋白激酶抑制剂对大鼠心房和主动脉平滑肌的影响。
Eur J Pharmacol. 1995 Feb 6;273(3):295-8. doi: 10.1016/0014-2999(94)00752-s.
10
Effects of calmidazolium, carbachol and derivatives of cyclic GMP on the longitudinal internal resistivity in rabbit atrial trabeculae.氯氮卓、卡巴胆碱及环磷酸鸟苷衍生物对兔心房小梁纵向内阻的影响。
J Physiol Pharmacol. 1991 Dec;42(4):397-406.

引用本文的文献

1
Nitric oxide regulates the calcium current in isolated human atrial myocytes.一氧化氮调节离体人心房肌细胞中的钙电流。
J Clin Invest. 1995 Feb;95(2):794-802. doi: 10.1172/JCI117729.
2
Influence of acetylcholine on the positive inotropic effect evoked by alpha- or beta-adrenoceptor stimulation in the rabbit heart.乙酰胆碱对家兔心脏中α或β肾上腺素能受体刺激所诱发的正性肌力作用的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1982 Aug;320(2):152-9. doi: 10.1007/BF00506315.
3
Signal transduction by cGMP in heart.心脏中cGMP介导的信号转导。

本文引用的文献

1
Generation and conduction of impulses in the heart as affected by drugs.药物对心脏冲动的产生和传导的影响。
Pharmacol Rev. 1963 Jun;15:277-332.
2
The recovery of resting potential and input resistance in sheep heart injured by knife or laser.刀伤或激光损伤的绵羊心脏静息电位和输入电阻的恢复
J Physiol. 1970 Jul;208(3):547-62. doi: 10.1113/jphysiol.1970.sp009136.
3
Cell-to-cell diffusion of procion yellow in sheep and calf Purkinje fibers.
J Membr Biol. 1974;16(4):381-8. doi: 10.1007/BF01872425.
Basic Res Cardiol. 1991 Nov-Dec;86(6):503-14. doi: 10.1007/BF02190700.
4
The permeability to tetraethylammonium ions of the surface membrane and the intercalated disks of sheep and calf myocardium.绵羊和小牛心肌表面膜及闰盘对四乙铵离子的通透性
J Physiol. 1974 Aug;240(3):741-62. doi: 10.1113/jphysiol.1974.sp010632.
5
Effect of dibutyryl cyclic GMP on cultured beating rat heart cells.二丁酰环鸟苷酸对培养的大鼠搏动心脏细胞的作用。
Adv Cyclic Nucleotide Res. 1972;1:301-5.
6
Changes in membrane currents in bullfrog atrium produced by acetylcholine.乙酰胆碱引起的牛蛙心房膜电流变化。
J Physiol. 1976 Sep;261(1):103-23. doi: 10.1113/jphysiol.1976.sp011550.
7
On the mechanism of the negative inotropic effect of acetylcholine.
Pflugers Arch. 1976 Feb 24;361(3):207-13. doi: 10.1007/BF00587284.
8
The action of acetylcholine on background conductance in frog atrial trabeculae.乙酰胆碱对蛙心耳小梁背景电导的作用。
J Physiol. 1978 Jan;274:381-96. doi: 10.1113/jphysiol.1978.sp012154.
9
The influence of dibutyryl cGMP on the rabbit auricle.
Pol J Pharmacol Pharm. 1978 Jan-Feb;30(1):73-5.
10
Are increases in cyclic GMP levels responsible for the negative inotropic effects of acetylcholine in the heart?
Biochem Biophys Res Commun. 1977 Dec 7;79(3):912-8. doi: 10.1016/0006-291x(77)91197-4.