Laboratory of Asymmetric Synthesis, Chemistry Institute of Natural Resources, Universidad de Talca, PO Box 747, Talca, Chile.
Anal Bioanal Chem. 2011 Apr;400(2):483-92. doi: 10.1007/s00216-011-4756-2. Epub 2011 Mar 5.
Polyamidoamine (PAMAM) dendrimers and water-soluble 3-mercaptopropionic acid (MPA)-capped CdSe quantum dots (QDs) were combined to produce a new gel containing supramolecular complexes of QDs/PAMAM dendrimers. The formation of the QDs/PAMAM supramolecular complexes was confirmed by high resolution electron microscopy and Fourier transform infrared (FTIR) analyses. Molecular dynamics simulations corroborated the structure of the new QDs/PAMAM-based supramolecular compound. Finally, on the basis of the prominent fluorescent properties of the supramolecular complexes, PAMAM dendrimer was functionalized with folic acid to produce a new QDs/PAMAM-folate derivative that showed an efficient and selective performance as a marker for gastric cancer cells.
聚酰胺-胺（PAMAM）树枝状大分子和水溶性 3-巯基丙酸（MPA）封端的 CdSe 量子点（QDs）被结合在一起，产生了一种含有 QDs/PAMAM 树枝状大分子超分子复合物的新型凝胶。通过高分辨率电子显微镜和傅里叶变换红外（FTIR）分析证实了 QDs/PAMAM 超分子复合物的形成。分子动力学模拟证实了新型基于 QDs/PAMAM 的超分子化合物的结构。最后，基于超分子复合物的突出荧光性质，将 PAMAM 树枝状大分子用叶酸进行功能化，得到了一种新型的 QDs/PAMAM-叶酸衍生物，该衍生物作为胃癌细胞的标志物表现出高效和选择性。
