Yan P, Liu D, Long M, Ren Y, Pang J, Li R
Department of Endocrinology, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing, China.
Exp Clin Endocrinol Diabetes. 2011 Apr;119(4):257-63. doi: 10.1055/s-0030-1269912. Epub 2011 Mar 3.
Omentin has recently been characterized as a potent insulin-sensitizing adipokine, but its pathophysiologic roles in humans remain largely unknown.
To investigate the change of fasting serum omentin levels and evaluate the relationship of omentin with adiponectin in patients with type 2 diabetes mellitus.
35 patients with newly diagnosed type 2 diabetes (T2DM), 35 patients with impaired glucose regulation (IGT) and 35 patients with normal glucose tolerance (NGT) participated in this study. Fasting serum omentin and adiponectin levels were measured by enzyme-linked immunosorbent assay. The relationship between serum omentin, serum adiponectin levels and metabolic parameters was also analyzed.
Fasting serum omentin levels were significantly lower in T2DM and IGT groups than in NGT group (16.75±1.71 vs. 18.62±1.22 vs. 24.60±1.43 ng/ml, all P<0.01). Obesity subjects had significantly lower serum omentin levels than normal body weight subjects ( P<0.01 or P<0.05). Female subjects had moderately higher fasting serum omentin levels than male subjects. Fasting serum adiponectin levels showed a similar variation trend to omentin in T2DM and NGT groups, obesity and normal body weight subjects, female and male subjects. Fasting serum omentin levels were negatively correlated with HOMA-IR and positively correlated with adiponectin. Moreover, HOMA-IR and adiponectin were the independently predictors of fasting serum omentin levels.
Serum omentin levels possibly play an important role in the pathogenesis of insulin resistance and diabetes. More importantly, there is such a close connection between serum omentin and adiponectin levels that regulation of omentin may be dependent on adiponectin.
网膜素最近被鉴定为一种有效的胰岛素增敏脂肪因子，但其在人类中的病理生理作用仍大多未知。
研究2型糖尿病患者空腹血清网膜素水平的变化，并评估网膜素与脂联素之间的关系。
35例新诊断的2型糖尿病（T2DM）患者、35例糖调节受损（IGT）患者和35例糖耐量正常（NGT）患者参与本研究。采用酶联免疫吸附测定法测量空腹血清网膜素和脂联素水平。还分析了血清网膜素、血清脂联素水平与代谢参数之间的关系。
T2DM组和IGT组的空腹血清网膜素水平显著低于NGT组（分别为16.75±1.71 vs. 18.62±1.22 vs. 24.60±1.43 ng/ml，均P<0.01）。肥胖受试者的血清网膜素水平显著低于正常体重受试者（P<0.01或P<0.05）。女性受试者的空腹血清网膜素水平略高于男性受试者。在T2DM组和NGT组、肥胖和正常体重受试者、女性和男性受试者中空腹血清脂联素水平显示出与网膜素相似的变化趋势。空腹血清网膜素水平与HOMA-IR呈负相关，与脂联素呈正相关。此外，HOMA-IR和脂联素是空腹血清网膜素水平的独立预测因素。
血清网膜素水平可能在胰岛素抵抗和糖尿病的发病机制中起重要作用。更重要的是，血清网膜素和脂联素水平之间存在如此密切的联系，以至于网膜素的调节可能依赖于脂联素。
